Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-cre/ERT2)1Aibs
• Allele Name: transgene insertion 1, Allen Institute for Brain Science
• Allele ID: MGI:4421787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pebp1^tm1.1Norm/Pebp1^tm1.1Norm Tg(Camk2a-cre/ERT2)1Aibs/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl	MGI:6450958

Genotype
MGI:6450958

cn1

• Allelic Composition: Pebp1^tm1.1Norm/Pebp1^tm1.1Norm; Tg(Camk2a-cre/ERT2)1Aibs/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:292694 )

N • normal appearance of axons and myelin sheaths in hippocampus and medial septal nucleus at age 18 months after knock-out induction at age 3 months

N • normal volume of cholinergic neuronal axon projections in secondary visual context at age 18 months after knock-out induction at age 3 months

abnormal hippocampus stratum oriens morphology ( J:292694 )

• reduced volume of cholinergic neuronal axon projections at age 18 months after knock-out induction at age 3 months

decreased summary potential intensity ( J:292694 )

• reduced local field potential (LFP) and theta power in hippocampal CA1 pyramidal layer at age 18 months after knock-out induction at age 3 months

behavior/neurological

behavior/neurological phenotype ( J:292694 )

N • normal behavior in open field, Y-maze, novel object recognition, tail suspension, and forced swimming tests at age 18 months after knock-out induction at age 3 months