Pebp1^tm1.1Norm
Targeted Allele Detail

Summary

• Symbol: Pebp1^tm1.1Norm
• Name: phosphatidylethanolamine binding protein 1; targeted mutation 1.1, Noriyuki Matsukawa
• MGI ID: MGI:6450937
• Synonyms: fHCNP-pp
• Gene: Pebp1 Location: Chr5:117420716-117425629 bp, - strand Genetic Position: Chr5, 56.88 cM
• Alliance: Pebp1^tm1.1Norm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292694
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the 5' UTR (12 bp upstream of the ATG start codon) and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 1-3 floxed. (J:292694)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pebp1 Mutation: 16 strains or lines available

References

• Original: J:292694 Madokoro Y, et al., Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice. Int J Mol Sci. 2019 Oct 28;20(21):5367
• All: 5 reference(s)