All Phenotypes Igh-J<tm1.1Lave> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave	Not Specified	MGI:4421674
ht2	Igh-J^tm1.1Lave/Igh-J⁺	Not Specified	MGI:4421673
cx3	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave Igk-J^tm1.1Lave/Igk-J^tm1.1Lave Tg(BCL2)22Wehi/0	involves: C57BL/6JWehi * SJL/JWehi	MGI:5306147
cx4	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave Igk-J^tm1.1Lave/Igk-J^tm1.1Lave	Not Specified	MGI:5306146

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:155798 )

• most 2F5-expressing B cells are deleted in the bone marrow at the pre-B to immature B cell stage

decreased immature B cell number ( J:155798 )

decreased transitional stage B cell number ( J:155798 )

• transitional B cell populations are decreased 20-fold compared to in wild-type mice

decreased transitional stage T1 B cell number ( J:155798 )

decreased transitional stage T2 B cell number ( J:155798 )

increased pro-B cell number ( J:155798 )

arrested B cell differentiation ( J:179317 )

• 2F5-expressing B cells fail to develop

decreased B cell number ( J:155798 , J:179317 )

• B cell numbers in the bone marrow and spleen are decreased compared to in wild-type mice (J:155798)

• in the bone marrow, spleen, lymph node, and Preyer's patch (J:179317)

decreased mature B cell number ( J:155798 )

• mice exhibit a decrease in mature splenic B cells with low surfgace Ig density compared to in wild-type mice

• however, the number of marginal zone and follicular mature B cells is normal

increased pre-B cell number ( J:155798 )

• the percentage of large pre-B cells in the bone marrow is increased compared to in wild-type mice

decreased T cell number ( J:155798 )

• in the spleen

decreased spleen weight ( J:155798 )

abnormal immunoglobulin level ( J:179317 )

• mice exhibit decreased immunoglobulin densities compared with wild-type mice

increased IgG level ( J:155798 )

decreased IgM level ( J:155798 )

hematopoietic system

abnormal B cell differentiation ( J:155798 )

• most 2F5-expressing B cells are deleted in the bone marrow at the pre-B to immature B cell stage

decreased immature B cell number ( J:155798 )

decreased transitional stage B cell number ( J:155798 )

• transitional B cell populations are decreased 20-fold compared to in wild-type mice

decreased transitional stage T1 B cell number ( J:155798 )

decreased transitional stage T2 B cell number ( J:155798 )

increased pro-B cell number ( J:155798 )

arrested B cell differentiation ( J:179317 )

• 2F5-expressing B cells fail to develop

decreased B cell number ( J:155798 , J:179317 )

• B cell numbers in the bone marrow and spleen are decreased compared to in wild-type mice (J:155798)

• in the bone marrow, spleen, lymph node, and Preyer's patch (J:179317)

decreased mature B cell number ( J:155798 )

• mice exhibit a decrease in mature splenic B cells with low surfgace Ig density compared to in wild-type mice

• however, the number of marginal zone and follicular mature B cells is normal

increased pre-B cell number ( J:155798 )

• the percentage of large pre-B cells in the bone marrow is increased compared to in wild-type mice

decreased T cell number ( J:155798 )

• in the spleen

decreased spleen weight ( J:155798 )

abnormal immunoglobulin level ( J:179317 )

• mice exhibit decreased immunoglobulin densities compared with wild-type mice

increased IgG level ( J:155798 )

decreased IgM level ( J:155798 )

Allelic Composition	Igh-J^tm1.1Lave/Igh-J⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1.1Lave mutation (0 available); any Igh-J mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:155798 )

• most 2F5-expressing B cells are deleted in the bone marrow at the pre-B to immature B cell stage

decreased immature B cell number ( J:155798 )

decreased transitional stage B cell number ( J:155798 )

• transitional B cell populations are decreased 7-fold compared to in wild-type mice

decreased transitional stage T1 B cell number ( J:155798 )

decreased transitional stage T2 B cell number ( J:155798 )

increased pro-B cell number ( J:155798 )

decreased B cell number ( J:155798 )

• B cell numbers in the bone marrow and spleen are decreased compared to in wild-type mice

decreased mature B cell number ( J:155798 )

• mice exhibit a decrease in mature splenic B cells with low surfgace Ig density compared to in wild-type mice

• however, the number of marginal zone and follicular mature B cells is normal

increased pre-B cell number ( J:155798 )

• the percentage of large pre-B cells in the bone marrow is increased compared to in wild-type mice

decreased T cell number ( J:155798 )

• in the spleen

decreased spleen weight ( J:155798 )

hematopoietic system

abnormal B cell differentiation ( J:155798 )

• most 2F5-expressing B cells are deleted in the bone marrow at the pre-B to immature B cell stage

decreased immature B cell number ( J:155798 )

decreased transitional stage B cell number ( J:155798 )

• transitional B cell populations are decreased 7-fold compared to in wild-type mice

decreased transitional stage T1 B cell number ( J:155798 )

decreased transitional stage T2 B cell number ( J:155798 )

increased pro-B cell number ( J:155798 )

decreased B cell number ( J:155798 )

• B cell numbers in the bone marrow and spleen are decreased compared to in wild-type mice

decreased mature B cell number ( J:155798 )

• mice exhibit a decrease in mature splenic B cells with low surfgace Ig density compared to in wild-type mice

• however, the number of marginal zone and follicular mature B cells is normal

increased pre-B cell number ( J:155798 )

• the percentage of large pre-B cells in the bone marrow is increased compared to in wild-type mice

decreased T cell number ( J:155798 )

• in the spleen

decreased spleen weight ( J:155798 )

Allelic Composition	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave Igk-J^tm1.1Lave/Igk-J^tm1.1Lave Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1.1Lave mutation (0 available); any Igh-J mutation (13 available)
Igk-J^tm1.1Lave mutation (0 available); any Igk-J mutation (11 available)
Tg(BCL2)22Wehi mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:179317 )

• B cell development is partially rescued

hematopoietic system

abnormal B cell differentiation ( J:179317 )

• B cell development is partially rescued

Allelic Composition	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave Igk-J^tm1.1Lave/Igk-J^tm1.1Lave
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:205708 )

• modest blockage at the pro/large pre-B to small pre-B transition

abnormal B cell clonal deletion ( J:179317 )

• mice exhibit increased clonal deletion compared with control mice

• however, clonal deletion is rescued by culturing immature sIg+ B cells in vitro with IL17 followed by BAFF (TNFSF13B) or in vitro culture of a population of 2F5 bnAb-producing naive sIg+ bone marrow B cells

decreased immature B cell number ( J:205708 )

arrested B cell differentiation ( J:179317 , J:205708 )

• more severe than in Igh-J^tm1.1Lave homozygotes (J:179317)

• B cell development is blocked at the small pre-B to immature B transition (J:205708)

decreased B cell number ( J:179317 , J:205708 )

• in the bone marrow, spleen, lymph node, and Preyer's patch (J:179317)

• in the bone marrow (J:205708)

decreased mature B cell number ( J:205708 )

abnormal B cell physiology ( J:205708 )

• B cells exhibit elevated basal activation and muted response to BCR ligation

abnormal immunoglobulin level ( J:179317 )

• mice exhibit lower immunoglobulin densities that is more severe than in Igh-J^tm1.1Lave homozygotes

hematopoietic system

abnormal B cell differentiation ( J:205708 )

• modest blockage at the pro/large pre-B to small pre-B transition

abnormal B cell clonal deletion ( J:179317 )

• mice exhibit increased clonal deletion compared with control mice

decreased immature B cell number ( J:205708 )

arrested B cell differentiation ( J:179317 , J:205708 )

• more severe than in Igh-J^tm1.1Lave homozygotes (J:179317)

• B cell development is blocked at the small pre-B to immature B transition (J:205708)

decreased B cell number ( J:179317 , J:205708 )

• in the bone marrow, spleen, lymph node, and Preyer's patch (J:179317)

• in the bone marrow (J:205708)

decreased mature B cell number ( J:205708 )

abnormal B cell physiology ( J:205708 )

• B cells exhibit elevated basal activation and muted response to BCR ligation

abnormal immunoglobulin level ( J:179317 )

• mice exhibit lower immunoglobulin densities that is more severe than in Igh-J^tm1.1Lave homozygotes

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