All Phenotypes Gad2<tm2(cre)Zjh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gad2^tm2(cre)Zjh/Gad2^tm2(cre)Zjh	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:4418723
cn2	Gad2^tm2(cre)Zjh/? Rai1^tm2.1Luo/Rai1^tm2.1Luo	either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)	MGI:5817645
cn3	Gabrd^tm1.1Jmag/Gabrd⁺ Gad2^tm2(cre)Zjh/Gad2⁺	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5527106

Allelic Composition	Gad2^tm2(cre)Zjh/Gad2^tm2(cre)Zjh
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2^tm2(cre)Zjh mutation (3 available); any Gad2 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:151755 )

• mice are viable, fertile, normal in size and display no gross physical or behavioral abnormalities

Allelic Composition	Gad2^tm2(cre)Zjh/? Rai1^tm2.1Luo/Rai1^tm2.1Luo
Genetic Background	either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2^tm2(cre)Zjh mutation (3 available); any Gad2 mutation (60 available)
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual memory recall

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:203336 )

• decreased seizure susceptibility in response 20mg/kg kainic acid as compared to controls

• decreased epilepitform activity over 120 min recording period

impaired ability to fire action potentials ( J:203336 )

• decreased average number of action potentials fired in CA1 pyramidal neurons in response to current injections above 40 pA

• decreased average number of action potentials fired in dentate gyrus granule cells in response to current injections above 60 pA

abnormal GABAergic neuron physiology ( J:203336 )

• decrease in tonic GABAergic currents recorded in interneurons from the molecular layer of the hippocampus as compared to controls

• decrease in tonic GABAergic currents recorded in interneurons from the stratum radiatum layer of the hippocampus as compared to controls

• increase in tonic GABAergic currents recorded in CA1 pyramidal neurons, however, no difference is observed in dentate gyrus granule cells as compared to controls

abnormal CNS synaptic transmission ( J:203336 )

• increase in spontaneous firing rate of stratum radiatum layer interneurons as compared to controls

• increase in firing rate of stratum radiatum layer interneurons in response to a single 1 s, 100 pA current injection as compared to controls

• increase in firing rate of molecular layer interneurons in response to a single 1 s, 100 pA current injection as compared to controls

• no differences are observed in resting potential or input resistance

increased excitatory postsynaptic current amplitude ( J:203336 )

• half maximal current amplitude (I₅₀) is increased in CA1 pyramidal neurons and dentate gyrus granule cells as compared to controls

abnormal inhibitory postsynaptic currents ( J:203336 )

• frequency of spontaneous IPSCs is increased in dentate gyrus granule cells (DGGCs) and CA1 pyramidal neurons

• peak amplitude of spontaneous IPSCs is increased in DGGCs and CA1 pyramidal neurons

• decrease in average inter-event interval (IEI) of spontaneous IPSCs

• increase in percentage of DGGCs and CA1 pyramidal cells following bursts of inhibitory postsynaptic currents as compared to control

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:203336 )

• decreased seizure susceptibility in response 20mg/kg kainic acid as compared to controls

• decreased epilepitform activity over 120 min recording period

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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