Analysis Tools
muscle
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• gastrocnemius and plantaris muscles from exercised mice without DOX do not show an increase in type I and type IIa fibers compared with sedentary mice, unlike in exercised controls
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Allele Symbol Allele Name Allele ID |
Tg(tetO-HDAC5*)1Eno transgene insertion 1, Eric N Olson MGI:4417969 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• gastrocnemius and plantaris muscles from exercised mice without DOX do not show an increase in type I and type IIa fibers compared with sedentary mice, unlike in exercised controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• DOX removal results in male death within 7-10 days and within about 30 days for female
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• after DOX withdrawal, males display decreased grooming 2 days before death
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• after DOX withdrawal, males become less responsive to handling 2 days before death
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• cristae are highly disturbed with large areas of blebbing in male mice 8 days after DOX withdrawal
• mitochondria appear swollen and 60% larger in male mice 8 days after DOX withdrawal
• the lipid body increase is reversed by 8 days after DOX withdrawal
• dramatic increase in lipid bodies in heart tissue of male mice 5 days after DOX withdrawal
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• cellular necrosis in males after DOX withdrawal
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• expression analysis shows inhibited PGC-1alpha and metabolic enzymes after DOX withdrawal
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• after DOX withdrawal, in unanesthetized males the heart rate is decreased to 230 beats per minute, compared with about 600 in normal littermates
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• inflammation is seen in males after DOX withdrawal
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• inflammation is seen in males after DOX withdrawal
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• dramatic increase in lipid bodies in heart tissue of male mice 5 days after DOX withdrawal
• the lipid body increase is reversed by 8 days after DOX withdrawal
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• expression analysis shows inhibited PGC-1alpha and metabolic enzymes after DOX withdrawal
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• cellular necrosis in males after DOX withdrawal
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• cellular necrosis in males after DOX withdrawal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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