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Allele Symbol Allele Name Allele ID |
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte transgene insertion 10, TaconicArtemis MGI:4417910 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a reduction in amyloid plaques compared with Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mice
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• mice exhibit a reduction in amyloid plaques compared with Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Amyloid pathology and glial inflammation in hemizygous and homozygous Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mouse brain
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• mice exhibit 85% survival
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• 2 of 13 mice die before 12 months of age
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• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mmice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala and related limbic structures, and thalamus unlike in wild-type mice
• plaques also accumulate in the olfactory bulb, colliculi, brainstem, and the striatum
• at 8 months, large plaques develop in the thalamus compared with wild-type mice
• older mice develop diffuse deposits of beta-amyloid
• plaque size increases with age
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• dense-core plaques are encompassed by a sphere of early-dystrophic, swollen neurites with ubiquitin accumulation unlike in wild-type mice
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• at 12 months, mice exhibit a deficit in episodic memory with reduced exploration of a novel object compared with wild-type mice
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• at 12 months, mice exhibit reduced performance in a Morris water maze test compared with wild-type mice
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• at 12 months, mice from the cross-sectional cohort display poor memory in a Morris water maze compared with wild-type mice
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• at 4 months but not in older mice, anxiety related behaviors are increased with mice spending less time in the center of an open field and entering the open sector of a zero maze compared with wild-type mice
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• at 12 months, mice exhibit a deficit in episodic memory with reduced exploration of a novel object compared with wild-type mice
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• at 4 months but not in older mice, exploratory activity is decreased in a Y maze compared with wild-type mice
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• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mmice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala and related limbic structures, and thalamus unlike in wild-type mice
• plaques also accumulate in the olfactory bulb, colliculi, brainstem, and the striatum
• at 8 months, large plaques develop in the thalamus compared with wild-type mice
• older mice develop diffuse deposits of beta-amyloid
• plaque size increases with age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:155410 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Amyloid pathology and glial inflammation in hemizygous and homozygous Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mouse brain
|
• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala, and related limbic structures unlike in wild-type mice
• at 10 to 11 months, large plaques develop in the thalamus unlike in wild-type mice
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• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala, and related limbic structures unlike in wild-type mice
• at 10 to 11 months, large plaques develop in the thalamus unlike in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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