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| Caption | Amyloid pathology and glial inflammation in Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mouse brain. B, Congo-red stained plaque core (red) in the frontal cortex of a Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0 (hemizygous) ARTE10 mouse at 5 months of age. The green bi-refringence in polarized light (inset) is diagnostic of amyloid. C, D, Thioflavin-S positive plaque cores (green), each encircled by a sphere (corona) of dilated, strongly ubiquitin-positive dystrophic neurites (red) in the subiculum of a Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte (homozygous) ARTE10 mouse at 3 months of age (D) and in the frontal cortex of a 19 months old hemizygous mouse (C), the latter with concomitant amyloid angiopathy (arrow). E, F, AT8-positive hyperphosphorylated tau (red) in dystrophic neurites adjacent to plaque cores (green: Ab40 and Ab42) in homozygous ARTE10 mice at 12 (E) and 8 (F) months of age. | ||||||
| Copyright | This image is from Willuweit A, PLoS One 2009;4(11):e7931, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155410 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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