Phenotypes associated with this allele

• Allele Symbol: Atg9a^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:4417824
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atg9a^tm1Aki/Atg9a^tm1Aki	involves: 129/Sv * C57BL/6	MGI:4417825

Genotype
MGI:4417825

hm1

• Allelic Composition: Atg9a^tm1Aki/Atg9a^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:155552 )

• MEFs fail to produce autophagasomes after growth under nutrient-starvation

impaired autophagy ( J:155552 )

• MEFs fail to produce autophagasomes after growth under nutrient-starvation

• decrease in the bulk degradation of long-lived proteins

mortality/aging

neonatal lethality, complete penetrance ( J:155552 )

• all die within 1 day of birth

cellular

abnormal autophagosome formation ( J:155552 )

• MEFs fail to produce autophagasomes after growth under nutrient-starvation

impaired autophagy ( J:155552 )

• MEFs fail to produce autophagasomes after growth under nutrient-starvation

• decrease in the bulk degradation of long-lived proteins

immune system

increased interferon-beta secretion ( J:155552 )

• expression and protein production of IFN-beta are increased in dsDNA stimulated MEFs

increased interleukin-6 secretion ( J:155552 )

• expression of interleukin-6 is increased in dsDNA stimulated MEFs

abnormal innate immunity ( J:155552 )

• abnormal response of MEFs to dsDNA stimulation