Phenotypes associated with this allele

• Allele Symbol: Etv2^tm1Dlim
• Allele Name: targeted mutation 1, Dae-Sik Lim
• Allele ID: MGI:4415819
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv2^tm1Dlim/Etv2^tm1Dlim	involves: C57BL/6	MGI:4415820
ht2	Etv2^tm1Dlim/Etv2^+	Not Specified	MGI:5009244
cn3	Etv2^tm1Dlim/Etv2^tm2.1Dlim Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJaeSor * C57BL/6 * CBA	MGI:5009245

Genotype
MGI:4415820

hm1

• Allelic Composition: Etv2^tm1Dlim/Etv2^tm1Dlim
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:155850 )

• die between E9.0 and E11.0

cardiovascular system

cardiovascular system phenotype ( J:155850 )

N • despite vascular defects, expression analysis indicates that cardiomyocyte development is relatively normal

abnormal blood vessel morphology ( J:155850 )

• fail to detect blood vessels in the embryo at E7.5, E8.5, and E9.5

abnormal placental labyrinth vasculature morphology ( J:155850 )

• vascularization has not started at E9.5

absent vitelline blood vessels ( J:155850 )

embryo

absent vitelline blood vessels ( J:155850 )

increased embryonic tissue cell apoptosis ( J:155850 )

• in the entire embryo at E9.5

embryonic growth retardation ( J:155850 )

• seen in all embryos at E9.5

decreased embryo size ( J:155850 )

• at E9.0

abnormal placenta labyrinth morphology ( J:155850 )

• labyrinth formation is delayed at E9.5

• labyrinth layer thickness is significantly decreased

abnormal placental labyrinth vasculature morphology ( J:155850 )

• vascularization has not started at E9.5

absent visceral yolk sac blood islands ( J:155850 )

pale yolk sac ( J:155850 )

abnormal embryonic erythropoiesis ( J:155850 )

• absence of primitive erythroid colonies at E8.5

abnormal placenta development ( J:155850 )

• labyrinth formation is delayed and vascularization has not started at E9.5

cellular

increased embryonic tissue cell apoptosis ( J:155850 )

• in the entire embryo at E9.5

hematopoietic system

abnormal embryonic erythropoiesis ( J:155850 )

• absence of primitive erythroid colonies at E8.5

growth/size/body

embryonic growth retardation ( J:155850 )

• seen in all embryos at E9.5

decreased embryo size ( J:155850 )

• at E9.0

Genotype
MGI:5009244

ht2

• Allelic Composition: Etv2^tm1Dlim/Etv2⁺
• Genetic Background: Not Specified

hematopoietic system

decreased hematopoietic stem cell number ( J:172687 )

• at 6 to 8 weeks of age

Genotype
MGI:5009245

cn3

• Allelic Composition: Etv2^tm1Dlim/Etv2^tm2.1Dlim; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

hematopoietic system

impaired myelopoiesis ( J:172687 )

• pIpC-treated mice exhibit a slightly decreased in the number of myeloid cells in the bone marrow and peripheral blood compared with control mice

decreased bone marrow cell number ( J:172687 )

• in pIpC-treated mice

abnormal myeloblast morphology/development ( J:172687 )

• pIpC-treated mice exhibit a decrease in the number of granulocyte-monocyte progenitors in the bone marrow compared with control mice

decreased leukocyte cell number ( J:172687 )

• slight in the peripheral blood of pIpC-treated mice

decreased hematopoietic stem cell number ( J:172687 )

• pIpC-treated mice exhibit reduced LSK cells, long-term hematopoietic stem cells, and short-term hematopoietic stem cells compared with control mice

spleen hypoplasia ( J:172687 )

• in pIpC-treated mice

abnormal hematopoietic stem cell physiology ( J:172687 )

• pIpC-treated mice exhibit increased apoptosis and decreased proliferation of LSK cells compared with control mice

• hematopoietic stem cells from pIpC-treated mice exhibit reduced repopulation capacity compared with cells from control mice

immune system

impaired myelopoiesis ( J:172687 )

• pIpC-treated mice exhibit a slightly decreased in the number of myeloid cells in the bone marrow and peripheral blood compared with control mice

decreased leukocyte cell number ( J:172687 )

• slight in the peripheral blood of pIpC-treated mice

spleen hypoplasia ( J:172687 )

• in pIpC-treated mice