Phenotypes associated with this allele

• Allele Symbol: Lrp6^tm1.2Cjz
• Allele Name: targeted mutation 1.2, Chengji J Zhou
• Allele ID: MGI:4415718
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp6^tm1.2Cjz/Lrp6^tm1.2Cjz	involves: C57BL/6J * CD-1 * SJL	MGI:4415734
ht2	Lrp6^tm1.2Cjz/Lrp6^Gt(Ex187)Byg	involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL	MGI:4415735

Genotype
MGI:4415734

hm1

• Allelic Composition: Lrp6^tm1.2Cjz/Lrp6^tm1.2Cjz
• Genetic Background: involves: C57BL/6J * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:155250 )

abnormal digit morphology ( J:155250 )

forelimb oligodactyly ( J:155250 )

• frequent forelimb oligodactyly

• digits reduced to 3-4

polydactyly ( J:155250 )

• low penetrance

abnormal forelimb morphology ( J:155250 )

• shortened or twisted forearms

• digital tendons duplicated dorsally

abnormal hindlimb morphology ( J:155250 )

• complete absence of distal structures

sirenomelia ( J:155250 )

• occurs in some mice

• proximal fusion of hindlimbs

short limbs ( J:155250 )

• forearms of forelimbs

short tail ( J:155250 )

• tail truncation

vision/eye

abnormal eye development ( J:155250 )

failure of eyelid fusion ( J:155250 )

• eyes of embryo are open

retina coloboma ( J:155250 )

• missing retina or defective retinal closure

microphthalmia ( J:155250 )

nervous system

spina bifida ( J:155250 )

exencephaly ( J:155250 )

craniofacial

cleft upper lip ( J:155250 )

• variable severity

cleft palate ( J:155250 )

• abnormal fusion

protruding tongue ( J:155250 )

digestive/alimentary system

cleft palate ( J:155250 )

• abnormal fusion

protruding tongue ( J:155250 )

reproductive system

abnormal external female genitalia morphology ( J:155250 )

♀ • complete absence

abnormal external male genitalia morphology ( J:155250 )

♂ • complete absence

embryo

sirenomelia ( J:155250 )

• occurs in some mice

• proximal fusion of hindlimbs

spina bifida ( J:155250 )

growth/size/body

cleft upper lip ( J:155250 )

• variable severity

cleft palate ( J:155250 )

• abnormal fusion

protruding tongue ( J:155250 )

Genotype
MGI:4415735

ht2

• Allelic Composition: Lrp6^tm1.2Cjz/Lrp6^Gt(Ex187)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL

limbs/digits/tail

abnormal limb morphology ( J:155250 )

• more severe in hind limbs than forelimbs

short tail ( J:155250 )

• tail truncation

vision/eye

abnormal eye development ( J:155250 )

failure of eyelid fusion ( J:155250 )

• eyes of embryo are open

retina coloboma ( J:155250 )

• missing retina or defective retinal closure

microphthalmia ( J:155250 )

nervous system

spina bifida ( J:155250 )

exencephaly ( J:155250 )

reproductive system

abnormal external female genitalia morphology ( J:155250 )

♀ • complete absence

abnormal external male genitalia morphology ( J:155250 )

♂ • complete absence

embryo

spina bifida ( J:155250 )