Analysis Tools
limbs/digits/tail
polydactyly
(
J:154920
)
|
• bilateral hindlimb-specific duplication of digit IV is observed
|
|
Allele Symbol Allele Name Allele ID |
Tbx2tm1.1(cre)Vmc targeted mutation 1.1, Vincent M Christoffels MGI:4415614 |
||||||||||||||||||||||||||||||||||||
| Summary |
8 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• bilateral hindlimb-specific duplication of digit IV is observed
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0
|
|
• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type
• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects
|
|
• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate
|
|
• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5
|
|
• bilateral hindlimb-specific duplication of digit IV is observed
|
|
• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0
|
|
• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type
• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects
|
|
• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate
|
|
• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5
|
|
• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0
|
|
• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type
• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects
|
|
• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate
|
|
• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are phenotypically normal on this outbred background
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit abrogation of myocardial patterning of the atrioventricular canal and largely lack the constriction between the left ventricle and atrium
|
|
• partial loss
|
|
• slightly retarded at E9.5
|
|
• slightly retarded at E9.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 11 of 13 embryos show complete cleft palate
|
|
• 11 of 13 embryos show complete cleft palate
|
|
• 11 of 13 embryos show complete cleft palate
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 5 of 13 embryos show complete cleft palate at E18.5
|
|
• 5 of 13 embryos show complete cleft palate at E18.5
|
|
• 5 of 13 embryos show complete cleft palate at E18.5
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||