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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xcl1tm1Rakr
targeted mutation 1, Richard A Kroczek
MGI:4415308
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xcl1tm1Rakr/Xcl1tm1Rakr B6.129-Xcl1tm1Rakr MGI:4415312
cx2
 		Xcl1tm1Rakr/Xcl1tm1Rakr
Tg(TcraTcrb)1100Mjb/0 		involves: 129/Sv * C57BL/6 MGI:4415311


Genotype
MGI:4415312
hm1
Allelic
Composition		 Xcl1tm1Rakr/Xcl1tm1Rakr
Genetic
Background		 B6.129-Xcl1tm1Rakr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xcl1tm1Rakr mutation (0 available); any Xcl1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:155297 )
N
• mice exhibit normal immune cell composition
decreased cytotoxic T cell cytolysis ( J:155297 )
• day 21 after immunization with ovalbumin

hematopoietic system
decreased cytotoxic T cell cytolysis ( J:155297 )
• day 21 after immunization with ovalbumin




Genotype
MGI:4415311
cx2
Allelic
Composition		 Xcl1tm1Rakr/Xcl1tm1Rakr
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)1100Mjb mutation (6 available)
Xcl1tm1Rakr mutation (0 available); any Xcl1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:155297 )
• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:155297 )
• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice
decreased cytotoxic T cell cytolysis ( J:155297 )
• 12 days after immunization in adoptive transfer experiments
decreased interferon-gamma secretion ( J:155297 )
• immunized T cells produce less IFN-gamma on day 12 compared with similarly treated wild-type cells

hematopoietic system
decreased T cell number ( J:155297 )
• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:155297 )
• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice
decreased cytotoxic T cell cytolysis ( J:155297 )
• 12 days after immunization in adoptive transfer experiments




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory