Phenotypes associated with this allele

• Allele Symbol: Tg(Hoxb7-Venus*)17Cos
• Allele Name: transgene insertion 17, Franklin Costantini
• Allele ID: MGI:4415296
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1Hass/Etv5^+ Tg(Hoxb7-Venus*)17Cos/0	involves: 129S1/Sv * C57BL/6J * CBA/J	MGI:4415622
cx2	4933425B07Rik^Tn(pb-Act-RFP)1.1Zhu/4933425B07Rik^Tn(pb-Act-RFP)1.1Zhu Tg(Hoxb7-Venus*)17Cos/0	involves: C57BL/6J * CBA/J * FVB/NJ	MGI:7424971

Genotype
MGI:4415622

cx1

• Allelic Composition: Etv4^tm1Arbr/Etv4^tm1Arbr; Etv5^tm1Hass/Etv5⁺; Tg(Hoxb7-Venus*)17Cos/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

absent kidney ( J:155594 )

• in most mice

abnormal ureter development ( J:155594 )

• at E11.5 to E12.5, 16% of ureteric buds are absent, 40% show no branching, 19% exhibit retarded branching compared to in wild-type mice

• when kidneys form they contain reduced numbers and irregularly patterned ureteric bud tips unlike in wild-type mice

• cultured ureteric buds fail to develop unlike wild-type samples and samples containing only one to two mutant alleles

Genotype
MGI:7424971

cx2

• Allelic Composition: 4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}/4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}; Tg(Hoxb7-Venus*)17Cos/0
• Genetic Background: involves: C57BL/6J * CBA/J * FVB/NJ

renal/urinary system

abnormal metanephric ureteric bud development ( J:313930 )

• expression levels of Bmp4 (a key gene regulating ureteral bud branching) are significantly reduced in the embryonic kidney during the early UB branching stages

impaired branching involved in ureteric bud morphogenesis ( J:313930 )

• in vitro, E11.5 embryonic kidneys show a significantly lower number of ureteric bud (UB) branches than control kidneys after 24, 48, and 72 h in culture