4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: 4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}
• Name: RIKEN cDNA 4933425B07 gene; transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:7266255
• Synonyms: Rik^PB
• Gene: 4933425B07Rik Location: Chr14:46840263-46874880 bp, - strand Genetic Position: Chr14, Syntenic
• Alliance: 4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Constitutively active)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. The transposon inserted into intron 3 of the gene, resulting in overexpression in homozygous mutant mice. RT-PCR of whole embryos and embryonic kidneys of E12.5 homozygous and heterozygous mice detected an increase in expression levels compared to that in wild type mice. (J:313930)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any 4933425B07Rik Mutation: 0 strains or lines available

References

• Original: J:313930 Tan L, et al., Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice. Front Cell Dev Biol. 2021;9:594640
• All: 2 reference(s)