Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv5tm1Hass mutation
(0 available);
any
Etv5 mutation
(270 available)
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mortality/aging
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• mice die prior to kidney development
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1Hass mutation
(0 available);
any
Etv5 mutation
(270 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1Hass mutation
(0 available);
any
Etv5 mutation
(270 available)
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renal/urinary system
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• hypoplastic kidneys are small and cystic, lack nephrogenic zone and have greatly reduced tubular elements and glomeruli compared to in wild-type mice
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• kidneys lack the nephorgenic zone
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1Hass mutation
(0 available);
any
Etv5 mutation
(270 available)
Tg(Hoxb7-Venus*)17Cos mutation
(1 available)
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renal/urinary system
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• at E11.5 to E12.5, 16% of ureteric buds are absent, 40% show no branching, 19% exhibit retarded branching compared to in wild-type mice
• when kidneys form they contain reduced numbers and irregularly patterned ureteric bud tips unlike in wild-type mice
• cultured ureteric buds fail to develop unlike wild-type samples and samples containing only one to two mutant alleles
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