All Phenotypes Grin2a<tm1.1Tnkw> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grin2a^tm1.1Tnkw
targeted mutation 1.1, Takanobu Nakazawa
MGI:4414793

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2a^tm1.1Tnkw/Grin2a^tm1.1Tnkw	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:4414795

Allelic Composition	Grin2a^tm1.1Tnkw/Grin2a^tm1.1Tnkw
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1.1Tnkw mutation (0 available); any Grin2a mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:155360 )

N	• mice exhibit normal spontaneous activity, fear conditioning, spatial working memory, acoustic startle response, pre-pulse inhibition, and responses to tail flick and hot plate

abnormal depression-related behavior ( J:155360 )

• when suspended by their tail or forced to swim, mice are less immobile than wild-type mice

nervous system

nervous system phenotype ( J:155360 )

N	• mice exhibit normal monoamine systems

abnormal excitatory postsynaptic currents ( J:155360 )

• NMDA-mediated excitatory postsynaptic current is not potentiated by Src unlike in similarly treated wild-type mice

reduced NMDA-mediated synaptic currents ( J:155360 )

• NMDA-mediated excitatory postsynaptic current is not potentiated by Src unlike in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24