Grin2a^tm1.1Tnkw
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1.1Tnkw
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1.1, Takanobu Nakazawa
• MGI ID: MGI:4414793
• Synonyms: NR2A^YF
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1.1Tnkw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155360
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 12 was replaced with a floxed neo cassette and a modified exon 12 containing nucleotide substitutions that result in the amino acid substitution of phenylalanine for tyrosine at position 1325 (Y1325F). The neo cassette was removed by cre mediated recombination. (J:155360)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 65 strains or lines available

References

• Original: J:155360 Taniguchi S, et al., Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J. 2009 Dec 2;28(23):3717-29
• All: 2 reference(s)