All Phenotypes Cd79a<tm2(cre/Esr1*)Reth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd79a^{tm2(cre/Esr1*)Reth}
targeted mutation 2, Michael Reth
MGI:4414764

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd79a^{tm2(cre/Esr1*)Reth}/Cd79a⁺ Rag1^tm1.1Sadu/Rag1^tm1.1Sadu	involves: BALB/c	MGI:4414770
cx2	Cd79a^{tm2(cre/Esr1*)Reth}/Cd79a⁺ Rag1^tm1.1Sadu/Rag1^tm1.1Sadu	involves: BALB/c	MGI:4414769

Allelic Composition	Cd79a^{tm2(cre/Esr1*)Reth}/Cd79a⁺ Rag1^tm1.1Sadu/Rag1^tm1.1Sadu
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^{tm2(cre/Esr1*)Reth} mutation (0 available); any Cd79a mutation (29 available)
Rag1^tm1.1Sadu mutation (0 available); any Rag1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:155473 )

N	• following administration of tamoxifen, mice produce IgM+ cells, do not accumulate c-kit+B220+ Pre/Pre B cells, and produce B1-a cells

Allelic Composition	Cd79a^{tm2(cre/Esr1*)Reth}/Cd79a⁺ Rag1^tm1.1Sadu/Rag1^tm1.1Sadu
Genetic Background	involves: BALB/c

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

arrested B cell differentiation ( J:155473 )

• mice exhibit a block in B cell development and are indistinguishable from Rag1^tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells

immune system

arrested B cell differentiation ( J:155473 )

• mice exhibit a block in B cell development and are indistinguishable from Rag1^tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells

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