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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79atm2(cre/Esr1*)Reth
targeted mutation 2, Michael Reth
MGI:4414764
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu 		involves: BALB/c MGI:4414770
cx2
 		Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu 		involves: BALB/c MGI:4414769


Genotype
MGI:4414770
cn1
Allelic
Composition		 Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm2(cre/Esr1*)Reth mutation (0 available); any Cd79a mutation (22 available)
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:155473 )
N
• following administration of tamoxifen, mice produce IgM+ cells, do not accumulate c-kit+B220+ Pre/Pre B cells, and produce B1-a cells




Genotype
MGI:4414769
cx2
Allelic
Composition		 Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm2(cre/Esr1*)Reth mutation (0 available); any Cd79a mutation (22 available)
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:155473 )
• mice exhibit a block in B cell development and are indistinguishable from Rag1tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells

immune system
arrested B cell differentiation ( J:155473 )
• mice exhibit a block in B cell development and are indistinguishable from Rag1tm1Mom homozygotes with an accumulation of c-kit+B220+ Pre/Pre B cells and absence of IgM+ cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory