Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation
(0 available);
any
Oprk1 mutation
(29 available)
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behavior/neurological
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• neither salvinorin A nor salvinorinyl-2-propionate induce analgesia
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation
(0 available);
any
Oprk1 mutation
(29 available)
|
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behavior/neurological
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• resistant to agonist U50,488-induced hypoactivity
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• resistant to agonist U50,488-induced analgesia as measured by a failure to exhibit increased warm water tail-flick latency
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nervous system
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• resistant to agonist U50,488-induced dopamine release in nucleus accumbens care and shell
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation
(0 available);
any
Oprk1 mutation
(29 available)
|
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behavior/neurological
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• fail to develop place aversion after systemic injection of the KOR agonist U50,488
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation
(0 available);
any
Oprk1 mutation
(29 available)
|
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|
behavior/neurological
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• U50,488 analgesic response is abolished compared to in wild-type mice
• however, improgan analgesic response is normal
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