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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Oprk1tm1Jep
targeted mutation 1, John E Pintar
MGI:4413460
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Oprk1tm1Jep/Oprk1tm1Jep involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 MGI:4437073
hm2
 		Oprk1tm1Jep/Oprk1tm1Jep involves: 129S/SvEv * C57BL/6 MGI:5824895
hm3
 		Oprk1tm1Jep/Oprk1tm1Jep involves: C57BL/6 MGI:4414755
hm4
 		Oprk1tm1Jep/Oprk1tm1Jep Not Specified MGI:4414642


Genotype
MGI:4437073
hm1
Allelic
Composition		 Oprk1tm1Jep/Oprk1tm1Jep
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation (0 available); any Oprk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemically-elicited antinociception ( J:157606 )
• neither salvinorin A nor salvinorinyl-2-propionate induce analgesia




Genotype
MGI:5824895
hm2
Allelic
Composition		 Oprk1tm1Jep/Oprk1tm1Jep
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation (0 available); any Oprk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor activation ( J:226396 )
• resistant to agonist U50,488-induced hypoactivity
abnormal chemically-elicited antinociception ( J:226396 )
• resistant to agonist U50,488-induced analgesia as measured by a failure to exhibit increased warm water tail-flick latency

nervous system
abnormal synaptic dopamine release ( J:226396 )
• resistant to agonist U50,488-induced dopamine release in nucleus accumbens care and shell




Genotype
MGI:4414755
hm3
Allelic
Composition		 Oprk1tm1Jep/Oprk1tm1Jep
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation (0 available); any Oprk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal avoidance learning behavior ( J:154773 )
• fail to develop place aversion after systemic injection of the KOR agonist U50,488




Genotype
MGI:4414642
hm4
Allelic
Composition		 Oprk1tm1Jep/Oprk1tm1Jep
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1Jep mutation (0 available); any Oprk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired behavioral response to anesthetic ( J:65217 )
• U50,488 analgesic response is abolished compared to in wild-type mice
• however, improgan analgesic response is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory