Oprk1^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Oprk1^tm1Jep
• Name: opioid receptor, kappa 1; targeted mutation 1, John E Pintar
• MGI ID: MGI:4413460
• Synonyms: KOR1, KOR-1
• Gene: Oprk1 Location: Chr1:5658689-5676354 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
• Alliance: Oprk1^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155295
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was replaced by a neomycin cassette via homologous recombination. Deletion was confirmed by absence of kappa-opioid agonist U69,593 binding. (J:155295, J:157606)

Expression

In Mice Carrying this Mutation:

35 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprk1 Mutation: 29 strains or lines available

References

• Original: J:155295 Zhang J, et al., Pintar production and analgesic characterization of KOR-1 deficient mice. Personal Communication. 1998;24(1):525 (Abstr.)
• All: 18 reference(s)