All Phenotypes Ret<tm1.1Ddg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm1.1Ddg
targeted mutation 1.1, David D Ginty
MGI:4413351

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm1.1Ddg/Ret^tm1.1Ddg	involves: 129	MGI:4413450
cx2	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret⁺	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:4413451
cx3	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret^tm1.1Ddg	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:4413452

Allelic Composition	Ret^tm1.1Ddg/Ret^tm1.1Ddg
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1.1Ddg mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• at E12.5, the common peroneal nerve is underdeveloped, especially in the distal limb, compared to in wild-type mice

• at E13.5, the peroneal nerve is thinner than in wild-type mice

• however, the tibial nerve is normal

• superficial and deep branches of the common peroneal nerve are stalled unlike in wild-type mice

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret⁺
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Ret^tm1.1Ddg mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• the peroneal nerve is shorter than in wild-type mice and Islr2^tm1.1Ddg homozygotes

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm1.1Ddg Ret^tm1.1Ddg/Ret^tm1.1Ddg
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• the peroneal nerve is shorter than in wild-type mice and Islr2^tm1.1Ddg homozygotes

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