Phenotypes associated with this allele
nervous system
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• at P14, GFP+ skin neuron projections are reduced and punctate unlike in control Mrgprdtm1Mjz Rettm1Ddg homozygotes
• however, central axonal projections in the thoracic spinal cord exhibit normal lamina specific innervation of peptidergic and nonpectidergic projections
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Rettm1Ddg mutation
(0 available);
any
Ret mutation
(53 available)
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mortality/aging
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• few mice survive beyond 3 weeks
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digestive/alimentary system
nervous system
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• at P14, non-peptidergic neurons are hypotrophic unlike in control Rettm1Ddg homozygotes
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• in the small intestine and colon
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• at P14, the dorsal root ganglia is 30% smaller than in control Rettm1Ddg homozygotes
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behavior/neurological
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• beginning at P3 mice develop progressive weakness
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growth/size/body