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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsx2tm2.1Kc
targeted mutation 2.1, Kenneth Campbell
MGI:4412065
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsx2tm2.1Kc/Gsx2tm2.1Kc involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4412085
cn2
 		Emx1tm1(cre)Krj/Emx1+
Gsx2tm2.1Kc/Gsx2tm2.1Kc
Tg(CAG-cat,-EGFP)1Rbns/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL MGI:4412088
cn3
 		Emx1tm1(cre)Krj/Emx1+
Gsx2tm2.1Kc/Gsx2tm2.1Kc 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4412086


Genotype
MGI:4412085
hm1
Allelic
Composition		 Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsx2tm2.1Kc mutation (0 available); any Gsx2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:154936 )
• mice appear normal




Genotype
MGI:4412088
cn2
Allelic
Composition		 Emx1tm1(cre)Krj/Emx1+
Gsx2tm2.1Kc/Gsx2tm2.1Kc
Tg(CAG-cat,-EGFP)1Rbns/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Gsx2tm2.1Kc mutation (0 available); any Gsx2 mutation (18 available)
Tg(CAG-cat,-EGFP)1Rbns mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb development ( J:154936 )
• mice exhibit respecification of olfactory bulb interneuron towards olfactory bulb projection neuron cell fate, as determined by marker expression




Genotype
MGI:4412086
cn3
Allelic
Composition		 Emx1tm1(cre)Krj/Emx1+
Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Gsx2tm2.1Kc mutation (0 available); any Gsx2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:154936 )
• mice exhibit defects in olfactory bulb neurogenesis, as determined by marker expression
abnormal olfactory bulb morphology ( J:154936 )
• mice exhibit defects in olfactory bulb neurogenesis, as determined by marker expression
abnormal lateral ganglionic eminence morphology ( J:154936 )
• mice exhibit respecification of null areas in the dorsal portion of the lateral ganglionic eminence toward a pallial cell fate

cellular
abnormal neuron differentiation ( J:154936 )
• mice exhibit defects in olfactory bulb neurogenesis, as determined by marker expression




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory