All Phenotypes Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0 Tg(Thy1-MAPT)183Gotz/0
Genetic Background	B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz mutation (1 available)
Tg(Thy1-MAPT)183Gotz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

tau protein deposits ( J:154968 )

• at 4 months, mice exhibit tau plaques unlike wild-type mice

• tau deposits worsen with age

behavior/neurological

abnormal spatial learning ( J:154968 )

• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice

• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice

increased locomotor activity ( J:154968 )

• in a novel arena at 2 and 12 months but not at 4 months

homeostasis/metabolism

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:154968
cerebral amyloid angiopathy	DOID:9246		J:154968

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

enhanced long-term potentiation ( J:165986 )

• induced by tetanic stimulation independent of age and amyloid plaque deposition

increased post-tetanic potentiation ( J:165986 )

• induced by tetanic stimulation

behavior/neurological

abnormal spatial learning ( J:154968 )

• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice

• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice

impaired coordination ( J:154968 )

• on at rotarod at 4 months

growth/size/body

increased body weight ( J:154968 )

• at 4 to 12 months

cellular

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

homeostasis/metabolism

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:165986

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23