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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr183tm1.1Cys
targeted mutation 1.1, Jason G Cyster
MGI:4399081
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr183tm1.1Cys/Gpr183tm1.1Cys B6.129P2-Gpr183tm1.1Cys MGI:4399082


Genotype
MGI:4399082
hm1
Allelic
Composition		 Gpr183tm1.1Cys/Gpr183tm1.1Cys
Genetic
Background		 B6.129P2-Gpr183tm1.1Cys
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr183tm1.1Cys mutation (0 available); any Gpr183 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal follicular B cell physiology ( J:151077 )
• in an adoptive transfer experiments, activated B cells fail to migrate from site of transfer and instead favor the central follicle unlike similarly treated wild-type cells
• however, activated B cell follicle localization is indistinguishable from that of wild-type cells in adoptive transfer experiments into Cxcl13tm1Cys homozygotes

hematopoietic system
abnormal follicular B cell physiology ( J:151077 )
• in an adoptive transfer experiments, activated B cells fail to migrate from site of transfer and instead favor the central follicle unlike similarly treated wild-type cells
• however, activated B cell follicle localization is indistinguishable from that of wild-type cells in adoptive transfer experiments into Cxcl13tm1Cys homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory