Phenotypes associated with this allele

• Allele Symbol: Zfp35^tm1Naka
• Allele Name: targeted mutation 1, Toshinori Nakayama
• Allele ID: MGI:4398896
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp35^tm1Naka/Zfp35^tm1Naka	either: B6.Cg-Zfp35^tm1Naka or C.Cg-Zfp35^tm1Naka	MGI:4398900

Genotype
MGI:4398900

hm1

• Allelic Composition: Zfp35^tm1Naka/Zfp35^tm1Naka
• Genetic Background: either: B6.Cg-Zfp35^tm1Naka or C.Cg-Zfp35^tm1Naka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 cell differentiation ( J:153828 )

• Th2 cell differentiation under Th2 conditions is enhanced compared with similarly treated wild-type cells

increased eosinophil cell number ( J:153828 )

• in the lungs of ovalbumin-inhaled mice

increased circulating interleukin-13 level ( J:153828 )

• 2- to 4-fold in anti-TCR beta-stimulated mice

increased circulating interleukin-4 level ( J:153828 )

• ovalbumin-treated mice exhibit an increase in IL4 levels compared with similarly treated wild-type mice

increased circulating interleukin-5 level ( J:153828 )

• anti-TCR beta-stimulated mice exhibit a 2- to 4-fold increase in IL5 compared with wild-type mice

• ovalbumin-treated mice exhibit an increase in IL5 levels compared with similarly treated wild-type mice

respiratory system

increased airway responsiveness ( J:153828 )

• methacholine-treated mice exhibit increased hyperresponsiveness compared with similarly treated wild-type mice

• ovalbumin-inhaled mice exhibit increased lung eosinophil infiltration, a mild increase in mucus production, and elevated levels of serum IL4 and IL5 compared with similarly treated wild-type mice

• ovalbumin-primed CD4 T cells transferred into donor mice increase airway inflammation and hyperresponsiveness to methacholine unlike wild-type cells

homeostasis/metabolism

increased circulating interleukin-13 level ( J:153828 )

• 2- to 4-fold in anti-TCR beta-stimulated mice

increased circulating interleukin-4 level ( J:153828 )

• ovalbumin-treated mice exhibit an increase in IL4 levels compared with similarly treated wild-type mice

increased circulating interleukin-5 level ( J:153828 )

• anti-TCR beta-stimulated mice exhibit a 2- to 4-fold increase in IL5 compared with wild-type mice

• ovalbumin-treated mice exhibit an increase in IL5 levels compared with similarly treated wild-type mice

hematopoietic system

abnormal T-helper 2 cell differentiation ( J:153828 )

• Th2 cell differentiation under Th2 conditions is enhanced compared with similarly treated wild-type cells

increased eosinophil cell number ( J:153828 )

• in the lungs of ovalbumin-inhaled mice