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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha4tm2Kldr
targeted mutation 2, Klas Kullander
MGI:4398683
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Epha4tm2Kldr/Epha4tm2Kldr
Tg(Pgk1-cre)1Lni/0 		involves: BALB/c * C57BL/6 MGI:4398699
cn2
 		Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+ 		involves: C57BL/6 MGI:4398696


Genotype
MGI:4398699
cn1
Allelic
Composition		 Epha4tm2Kldr/Epha4tm2Kldr
Tg(Pgk1-cre)1Lni/0
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm2Kldr mutation (0 available); any Epha4 mutation (68 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal anterior commissure morphology ( J:154648 )
• the anterior commissure does not form in its normal location
abnormal spinal cord dorsal column morphology ( J:154648 )
• the ventral part of the dorsal funiculus is reduced and the distance between the dorsal funiculus and the central canal is increased compared to in Epha4tm2Kldr control mice

behavior/neurological
abnormal gait ( J:154648 )
• mice exhibit a hopping gait unlike Epha4tm2Kldr control mice




Genotype
MGI:4398696
cn2
Allelic
Composition		 Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm2.1Kldr mutation (0 available); any Epha4 mutation (68 available)
Epha4tm2Kldr mutation (0 available); any Epha4 mutation (68 available)
Grik4tm1.1(cre)Slab mutation (2 available); any Grik4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:154648 )
N
• mice exhibit normal long term potentiation and excitatory postsynaptic potential to theta burst- and tetanus-induced stimulation




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory