Phenotypes associated with this allele

• Allele Symbol: Ilk^tm9.1Ref
• Allele Name: targeted mutation 9.1, Reinhard Fassler
• Allele ID: MGI:4368013
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ilk^tm9.1Ref/Ilk^tm9.1Ref	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:4397490

Genotype
MGI:4397490

hm1

• Allelic Composition: Ilk^tm9.1Ref/Ilk^tm9.1Ref
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:154054 )

• all mice die shortly after birth

renal/urinary system

increased metanephric mesenchyme apoptosis ( J:154054 )

• by E12.5 and E13.5, the metanephric mesenchyme exhibits increased apoptosis compared to in wild-type mice

decreased kidney collecting duct number ( J:154054 )

• reduced in number in the kidneys that do develop

renal hypoplasia ( J:154054 )

• 3% of mice exhibit dysgenic or hypoplastic kidneys

decreased nephron number ( J:154054 )

• reduced nephron number in the kidneys that do develop

absent kidney ( J:154054 )

• in 70% of mice

single kidney ( J:154054 )

• in 27% of mice

absent ureter ( J:154054 )

• in 8% of mice lacking one or both kidneys

impaired branching involved in ureteric bud morphogenesis ( J:154054 )

• at E12.5 and E13.5, ureteric bud branching is impaired unlike in wild-type mice

• ureteric buds fail to branch in vitro in response to GDNF-containing matrigel unlike similarly treated wild-type cells

abnormal ureteric bud invasion ( J:154054 )

• at E11.5, no ureteric bud is detected in the metanephric mesenchyme unlike in wild-type mice

• urogenital blocks grown in vitro and stimulated with GDNF fail to form ectopic ureteric buds unlike similarly treated wild-type tissue

• ureteric buds prevent wild-type metanephric mesenchyme from undergoing nephrogenesis when combined

anuria ( J:154054 )

• no urine collects in the bladders of mice that do develop kidneys

behavior/neurological

aphagia ( J:154054 )

• mice fail to eat at birth

hunched posture ( J:154054 )

• at birth, mice exhibit a bent body posture unlike wild-type mice

growth/size/body

decreased birth body size ( J:154054 )

embryo

increased metanephric mesenchyme apoptosis ( J:154054 )

• by E12.5 and E13.5, the metanephric mesenchyme exhibits increased apoptosis compared to in wild-type mice

abnormal mesonephros morphology ( J:154054 )

• mesonephros contain fewer mesonephric tubules compared to in wild-type tissue

• mesonephros stimulated with lithium fail to form brush-boarder-positive proximal tubules unlike similarly treated wild-type tissue

cardiovascular system

cardiovascular system phenotype ( J:154054 )

N • mice do not exhibit heart defects

integument

integument phenotype ( J:154054 )

N • mice do not exhibit skin defects

pallor ( J:154054 )

• at birth

cellular

increased metanephric mesenchyme apoptosis ( J:154054 )

• by E12.5 and E13.5, the metanephric mesenchyme exhibits increased apoptosis compared to in wild-type mice