Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Grin1 mutation
(64 available)
Grin1tm2.1Stl mutation
(0 available);
any
Grin1 mutation
(64 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation
(5 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Slc6a4-cre)ET127Gsat mutation
(1 available)
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nervous system
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• disruption of somatic innervation during development in the absence of NMDARs at P14
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Grin1 mutation
(64 available)
Grin1tm2.1Stl mutation
(0 available);
any
Grin1 mutation
(64 available)
Tg(Slc6a4-cre)ET127Gsat mutation
(1 available)
|
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|
nervous system
|
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
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• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
|
|
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
|
|
• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Grin1 mutation
(64 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation
(5 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Slc6a4-cre)ET127Gsat mutation
(1 available)
|
|
|
nervous system
|
• disruption of somatic innervation during development in the absence of NMDARs at P14
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Grin1 mutation
(64 available)
Tg(Slc6a4-cre)ET127Gsat mutation
(1 available)
|
|
|
nervous system
|
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
|
|
• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
|
|
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
|
|
• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13
|