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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dclre1ctm2.2Jpdv
targeted mutation 2.2, Jean-Pierre de Villartay
MGI:4366774
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv B6.129S2-Dclre1ctm2.2Jpdv MGI:4366789
cn2
Dclre1ctm2.1Jpdv/Dclre1ctm2.2Jpdv
Tg(Cr2-cre)3Cgn/0
involves: 129S2/SvPas * C57BL/6 MGI:4366790


Genotype
MGI:4366789
hm1
Allelic
Composition
Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic
Background
B6.129S2-Dclre1ctm2.2Jpdv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1ctm2.2Jpdv mutation (0 available); any Dclre1c mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit a 6-fold reduction in blood mononuclear cells compared with wild-type mice
• B220+IgM+ immature B cells are absent
• at the proB-preB immature stage in the bone marrow
• at the CD4-CD8- double negative progenitor stage

hematopoietic system
• mice exhibit a 6-fold reduction in blood mononuclear cells compared with wild-type mice
• B220+IgM+ immature B cells are absent
• at the proB-preB immature stage in the bone marrow
• at the CD4-CD8- double negative progenitor stage

endocrine/exocrine glands




Genotype
MGI:4366790
cn2
Allelic
Composition
Dclre1ctm2.1Jpdv/Dclre1ctm2.2Jpdv
Tg(Cr2-cre)3Cgn/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1ctm2.1Jpdv mutation (1 available); any Dclre1c mutation (30 available)
Dclre1ctm2.2Jpdv mutation (0 available); any Dclre1c mutation (30 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal B cell development and Ig titers
• class switching to IgG3 is decreased 23% compared to in wild-type mice
• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice
• class switch recombination junctions are altered compared to in wild-type mice

hematopoietic system
• class switching to IgG3 is decreased 23% compared to in wild-type mice
• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice
• class switch recombination junctions are altered compared to in wild-type mice





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory