Dclre1c^tm2.2Jpdv
Targeted Allele Detail

Summary

• Symbol: Dclre1c^tm2.2Jpdv
• Name: DNA cross-link repair 1C; targeted mutation 2.2, Jean-Pierre de Villartay
• MGI ID: MGI:4366774
• Synonyms: Art^-
• Gene: Dclre1c Location: Chr2:3425168-3465167 bp, + strand Genetic Position: Chr2, 1.93 cM
• Alliance: Dclre1c^tm2.2Jpdv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153841
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Transient cre expression mediated removal of exon 12 and the neo cassette. The absence of transcript expression containing exons 1 through 12 was confirmed by RT-PCR on spleen extracts; however, RT-PCR using primers spanning exons 1 through 14 detected a truncated transcript. (J:153841)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dclre1c Mutation: 30 strains or lines available

References

• Original: J:153841 Rivera-Munoz P, et al., Reduced immunoglobulin class switch recombination in the absence of Artemis. Blood. 2009 Oct 22;114(17):3601-9
• All: 1 reference(s)