All Phenotypes Atp7a<Mo-3Btlr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp7a^Mo-3Btlr
mottled 3 Bruce Beutler
MGI:4366761

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp7a^Mo-3Btlr/Atp7a^Mo-3Btlr	C57BL/6J-Atp7a^Mo-3Btlr	MGI:4366762
ht2	Atp7a^Mo-3Btlr/Atp7a⁺	C57BL/6J-Atp7a^Mo-3Btlr	MGI:5441737
ot3	Atp7a^Mo-3Btlr/Y	C57BL/6J-Atp7a^Mo-3Btlr	MGI:4366763

Allelic Composition	Atp7a^Mo-3Btlr/Atp7a^Mo-3Btlr
Genetic Background	C57BL/6J-Atp7a^Mo-3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-3Btlr mutation (1 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

pigmentation

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

• brown coat color with normal pigmentation of the skin and eyes (J:153280)

(J:188598)

integument

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

• brown coat color with normal pigmentation of the skin and eyes (J:153280)

(J:188598)

Allelic Composition	Atp7a^Mo-3Btlr/Atp7a⁺
Genetic Background	C57BL/6J-Atp7a^Mo-3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-3Btlr mutation (1 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

integument

integument phenotype ( J:188598 )

N	• unlike other mutations in this gene, heterozygotes do not present with variegated coat color

Allelic Composition	Atp7a^Mo-3Btlr/Y
Genetic Background	C57BL/6J-Atp7a^Mo-3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-3Btlr mutation (1 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

pigmentation

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

• brown coat color with normal pigmentation of the skin and eyes (J:153280)

(J:188598)

homeostasis/metabolism

decreased brain copper level ( J:188598 )

• decreased by 60% compared to control littermates

immune system

decreased susceptibility to prion infection ( J:188598 )

• following intracranial infection with the Rocky Mountain Laboratory strain of mouse scrapie only 1 of 10 mice became sick within 161 days after infection while all wild-type controls became ill in the same time span

• all mice became terminally ill by 180 days post scrapie infection

• the amount of proteinase-resistant prion protein in the brains of clinically ill mice is reduced compared to controls

nervous system

decreased brain copper level ( J:188598 )

• decreased by 60% compared to control littermates

integument

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

• brown coat color with normal pigmentation of the skin and eyes (J:153280)

(J:188598)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23