About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l11tm3.1Boui
targeted mutation 3.1, Philippe Bouillet
MGI:4366756
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui C57BL/6-Bcl2l11tm3.1Boui MGI:4366830
cx2
 		Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui 		B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui MGI:4366837
cx3
 		Bcl2l11tm3.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0 		involves: C57BL/6 * SJL MGI:5433595
cx4
 		Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Tg(IghMyc)22Bri/0 		involves: C57BL/6 * SJL MGI:5433596


Genotype
MGI:4366830
hm1
Allelic
Composition		 Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic
Background		 C57BL/6-Bcl2l11tm3.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:153846 )
• smaller increase in spleen weight (<1.5 fold)
increased leukocyte cell number ( J:153846 )
• smaller increase in white blood cells numbers (<1.5 fold)

immune system
immune system phenotype ( J:153846 )
N
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
increased spleen weight ( J:153846 )
• smaller increase in spleen weight (<1.5 fold)
increased leukocyte cell number ( J:153846 )
• smaller increase in white blood cells numbers (<1.5 fold)

growth/size/body
increased spleen weight ( J:153846 )
• smaller increase in spleen weight (<1.5 fold)




Genotype
MGI:4366837
cx2
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

The Bcl2l11tm3.1Boui mutation ameliorates the degenerative disorders of Bcl2tm1Dlo/Bcl2tm1Dlo mice

mortality/aging
premature death ( J:153846 )
• live up to 300 days due to mild polycystic kidney disease (PKD)

growth/size/body
polycystic kidney ( J:153846 )
• mild signs of polycystic kidney disease (PKD)
• progress slowly
• live up to 300 days
postnatal growth retardation ( J:153846 )
• retarded growth
• most of these animals (n = 24) become healthy adults
increased spleen weight ( J:153846 )
• spleens are heavier than those in homozygous Bcl-2 deficient mice

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure
decreased splenocyte apoptosis ( J:153846 )
• less apoptosis than in homozygous Bcl-2 deficient mice spleen
increased spleen weight ( J:153846 )
• spleens are heavier than those in homozygous Bcl-2 deficient mice
increased leukocyte cell number ( J:153846 )
• more white blood cells numbers than in homozygous Bcl-2 deficient mice

renal/urinary system
polycystic kidney ( J:153846 )
• mild signs of polycystic kidney disease (PKD)
• progress slowly
• live up to 300 days

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure
decreased splenocyte apoptosis ( J:153846 )
• less apoptosis than in homozygous Bcl-2 deficient mice spleen
increased spleen weight ( J:153846 )
• spleens are heavier than those in homozygous Bcl-2 deficient mice
increased leukocyte cell number ( J:153846 )
• more white blood cells numbers than in homozygous Bcl-2 deficient mice

cellular
decreased splenocyte apoptosis ( J:153846 )
• less apoptosis than in homozygous Bcl-2 deficient mice spleen




Genotype
MGI:5433595
cx3
Allelic
Composition		 Bcl2l11tm3.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Tg(IghMyc)22Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median lifespan is 110 days, which is similar to single Tg(IghMyc)22Bri hemizygotes

neoplasm
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)




Genotype
MGI:5433596
cx4
Allelic
Composition		 Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Tg(IghMyc)22Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median lifespan is 84 days, which is not statistically different from single Tg(IghMyc)22Bri hemizygotes

neoplasm
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mix of sIg- pre-B lymphoma (~50%) and sIg+ B lymphoma (~50%)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory