About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l11tm2.1Boui
targeted mutation 2.1, Philippe Bouillet
MGI:4366751
Summary 6 genotypes


Genotype
MGI:4366827
hm1
Allelic
Composition		 Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 C57BL/6-Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

immune system
immune system phenotype ( J:153846 )
N
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

growth/size/body
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)




Genotype
MGI:4366831
ht2
Allelic
Composition		 Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 C57BL/6-Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

immune system
immune system phenotype ( J:153846 )
N
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

growth/size/body
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)




Genotype
MGI:4366840
cx3
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
increased leukocyte cell number ( J:153846 )
• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

renal/urinary system
renal/urinary system phenotype ( J:153846 )
N
• mice do not develop polycystic kidney disease

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
increased leukocyte cell number ( J:153846 )
• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

growth/size/body
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice




Genotype
MGI:4366836
cx4
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice

growth/size/body
growth/size/body region phenotype ( J:153846 )
N
• grow normally

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure

renal/urinary system
renal/urinary system phenotype ( J:153846 )
N
• mice do not develop polycystic kidney disease diluted coat color [MP:0000371]

pigmentation
diluted coat color ( J:153846 )
• coat color becomes gray at 5 to 7 weeks of age

integument
diluted coat color ( J:153846 )
• coat color becomes gray at 5 to 7 weeks of age




Genotype
MGI:5433585
cx5
Allelic
Composition		 Bcl2l11tm2.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Tg(IghMyc)22Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• average survival is 70 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days

neoplasm
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)

hematopoietic system
increased leukocyte cell number ( J:186117 )
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

immune system
increased leukocyte cell number ( J:186117 )
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes




Genotype
MGI:5433594
cx6
Allelic
Composition		 Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Tg(IghMyc)22Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median survival of 58 days

neoplasm
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mixture of sIg- pre-B lymphoma (~60%) and sIg+ B lymphoma (~40%)

hematopoietic system
increased leukocyte cell number ( J:186117 )
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes

immune system
increased leukocyte cell number ( J:186117 )
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory