Phenotypes associated with this allele

• Allele Symbol: Casp3^mldy
• Allele Name: melody
• Allele ID: MGI:4366356
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp3^mldy/Casp3^mldy	either: C3H.B6-Casp3^mldy or (involves: C3H/HeH * C57BL/6J)	MGI:4366357

Genotype
MGI:4366357

hm1

• Allelic Composition: Casp3^mldy/Casp3^mldy
• Genetic Background: either: C3H.B6-Casp3^mldy or (involves: C3H/HeH * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absent startle reflex ( J:153800 )

• no response to a clickbox

craniofacial

cranial bossing ( J:153800 )

• a small number of homozygous mice display cranial protrusions; this is observed in roughly half of homozygous embryos at E17.5

hearing/vestibular/ear

abnormal cochlear hair cell morphology ( J:153800 )

• fusion of the sensory hair cells of the cochlea

cochlear hair cell degeneration ( J:153800 )

increased or absent threshold for auditory brainstem response ( J:153800 )

• no response to 90dB SPL acoustic brain response (ABR) stimulus

deafness ( J:153800 )

• by 30 days of age

nervous system

abnormal cochlear hair cell morphology ( J:153800 )

• fusion of the sensory hair cells of the cochlea

cochlear hair cell degeneration ( J:153800 )

cochlear ganglion degeneration ( J:153800 )

• degeneration of the spiral ganglion neurons

skeleton

cranial bossing ( J:153800 )

• a small number of homozygous mice display cranial protrusions; this is observed in roughly half of homozygous embryos at E17.5