Casp3^mldy
Chemically induced Allele Detail

Summary

• Symbol: Casp3^mldy
• Name: caspase 3; melody
• MGI ID: MGI:4366356
• Gene: Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
• Alliance: Casp3^mldy page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, discovered in a screen of the progeny of an ENU mutagenized mouse, has been identified as a G to C transversion at nucleotide 489 of the exonic sequence, in exon 6 of the gene, that results in replacement of the catalytic cysteine at amino acid position 163 by serine (C163S). (J:153800, J:166750)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp3 Mutation: 31 strains or lines available

References

• Original: J:153800 Parker A, et al., melody, an ENU mutation in Caspase-3, alters the catalytic cycteine residue and causes sensorineural hearing loss in mice. MGI Direct Data Submission. 2009
• All: 2 reference(s)