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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2rtm1.1Cgh
targeted mutation 1.1, Shaun R Coughlin
MGI:4365911
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		F2rtm1.1Cgh/F2rtm1.1Cgh
F2rl1tm2Cgh/F2rl1tm2Cgh
Tg(Tek-F2r)1Cgh/0 		involves: 129S4/SvJae * C57BL/6 MGI:4438100


Genotype
MGI:4438100
cx1
Allelic
Composition		 F2rtm1.1Cgh/F2rtm1.1Cgh
F2rl1tm2Cgh/F2rl1tm2Cgh
Tg(Tek-F2r)1Cgh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm2Cgh mutation (0 available); any F2rl1 mutation (58 available)
F2rtm1.1Cgh mutation (1 available); any F2r mutation (23 available)
Tg(Tek-F2r)1Cgh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:157446 )
N
• presence of the transgene recues the lethality observed in double null animals; number of embryos observed at 12.5-14.5 days post coitus is equal to number of wild-type embryos collected

nervous system
exencephaly ( J:157446 )
• transgene expression does not prevent exencephaly with about 20% embryos at 12.5-14.5 dpc

cardiovascular system
cardiovascular system phenotype ( J:157446 )
N
• lethality associated with midgestational cardiovascular failure is rescued




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory