Tg(Tek-F2r)1Cgh
Transgene Detail

Summary

• Symbol: Tg(Tek-F2r)1Cgh
• Name: transgene insertion 1, Shaun R Coughlin
• MGI ID: MGI:4438039
• Synonyms: TIE2p/e-PAR1
• Transgene: Tg(Tek-F2r)1Cgh Location: unknown
• Alliance: Tg(Tek-F2r)1Cgh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tek-F2r)1Cgh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	F2r (MGI:101802)

• Mutation details: The endothelial-specific Tie2 (Tek) promoter/enhancer drives expression of the mouse Par1 (F2r) gene. The construct consists of the Tek promoter (endothelial-specific) wuth F2r cDNA and SV40 polyA sequence, followed by the Tek endothelial-specific enhancer. Selective expression of transgenic F2r can be detected by E8.0 in the endothelium and endocardium by RT-PCR. Two independent founders were generated and displayed similar results when crossed onto the F2r^tm1.1Cgh background. Line 1 was chosen to designate this line. (J:71309)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:71309 Griffin CT, et al., A role for thrombin receptor signaling in endothelial cells during embryonic development. Science. 2001 Aug 31;293(5535):1666-70
• All: 2 reference(s)