Phenotypes associated with this allele

• Allele Symbol: Cdsn^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:4365388
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdsn^tm1.1Ics/Cdsn^tm1.1Ics Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas	MGI:4365390
cn2	Cdsn^tm1.1Ics/Cdsn^tm1.1Ics Tg(KRT14-cre)1Ipc/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4365389

Genotype
MGI:4365390

cn1

• Allelic Composition: Cdsn^tm1.1Ics/Cdsn^tm1.1Ics; Tg(KRT14-cre/ERT2)1Ipc/0
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153292 )

• after intraperitoneal injection of tamoxifen mice need to be euthanized within 5 days of the development of the abnormal skin phenotype

endocrine/exocrine glands

sebaceous gland hypertrophy ( J:153292 )

• seen after tamoxifen treatment

growth/size/body

weight loss ( J:153292 )

• seen after the development of the abnormal skin phenotype induced by intraperitoneal injection of tamoxifen

homeostasis/metabolism

impaired skin barrier function ( J:153292 )

• in tamoxifen treated mice, progressive increase in trans epidermal water loss is seen coinciding with the appearance and progression of the scaly skin phenotype

immune system

skin inflammation ( J:153292 )

• moderate inflammation is seen in the early stages of phenotype development after topical treatment with tamoxifen

integument

sebaceous gland hypertrophy ( J:153292 )

• seen after tamoxifen treatment

impaired skin barrier function ( J:153292 )

• in tamoxifen treated mice, progressive increase in trans epidermal water loss is seen coinciding with the appearance and progression of the scaly skin phenotype

skin inflammation ( J:153292 )

• moderate inflammation is seen in the early stages of phenotype development after topical treatment with tamoxifen

distended hair follicles ( J:153292 )

• after tamoxifen treatment hair follicles appear distended

hair follicle degeneration ( J:153292 )

• at later stages after tamoxifen treatment hair follicles disappear

hyperkeratosis ( J:153292 )

• seen after tamoxifen treatment

parakeratosis ( J:153292 )

• seen after tamoxifen treatment

acanthosis ( J:153292 )

• seen after tamoxifen treatment

scaly skin ( J:153292 )

• after tamoxifen treatment mice develop scales that first appear on the ventral side and snout then extend to the back and whole body

spontaneous skin ulceration ( J:153292 )

• after topical tamoxifen treatment ulcerations appear associated with shedding of large scale and complete loss of the epidermis

Genotype
MGI:4365389

cn2

• Allelic Composition: Cdsn^tm1.1Ics/Cdsn^tm1.1Ics; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

mortality/aging

neonatal lethality, complete penetrance ( J:153292 )

• die within 1 to 2 h of birth

homeostasis/metabolism

impaired skin barrier function ( J:153292 )

• impaired barrier function coincides with areas of skin detachment

• trans epidermal water loss increases dramatically after the onset of skin detachment

• dorsal skin grafted onto nude mice displays increased trans epidermal water loss

neoplasm

increased skin papilloma incidence ( J:153292 )

• papillomatosis is seen in dorsal skin grafted onto nude mice

integument

impaired skin barrier function ( J:153292 )

• impaired barrier function coincides with areas of skin detachment

• trans epidermal water loss increases dramatically after the onset of skin detachment

• dorsal skin grafted onto nude mice displays increased trans epidermal water loss

hairless ( J:153292 )

• dorsal skin grafted onto nude mice initially has sparse hairs that progressively disappear becoming totally absent by 9 weeks after grafting

mixed cellular infiltration to dermis ( J:153292 )

• seen in dorsal skin grafted onto nude mice

abnormal epidermal layer morphology ( J:153292 )

• blisters are seen between the stratum granulosum and stratum corneum

• in isolated sections of skin and in areas adjacent to zones of detachment at the transition from the stratum granulosum to the stratum corneum numerous split transitional desmosomes are seen

absent epidermis stratum corneum ( J:153292 )

• in zones of skin rupture

• however, the stratum corneum is present in areas with intact skin

hyperkeratosis ( J:153292 )

• seen in dorsal skin grafted onto nude mice

parakeratosis ( J:153292 )

• seen in dorsal skin grafted onto nude mice

epidermal hyperplasia ( J:153292 )

• prominent hyperplasia with papillomatosis is seen in dorsal skin grafted onto nude mice

spontaneous skin ulceration ( J:153292 )

• grafting of dorsal skin onto nude mice results in chronic ulceration of the grafted skin

abnormal skin condition ( J:153292 )

• severe skin detachment is seen in neonates

• when born by C-section mice appear normal until groomed by surrogate mothers after which skin detachment is rapidly apparent

• skin rupture starts in the ventral area, paws and snout and extends to the flanks

• dorsal skin grafted onto nude mice becomes hard and forms a scab that by 9 weeks post grafting completely replaces the epidermis

dermal cyst ( J:153292 )

• seen in dorsal skin grafted onto nude mice, characteristically result from degenerative hair follicles

increased skin papilloma incidence ( J:153292 )

• papillomatosis is seen in dorsal skin grafted onto nude mice

decreased skin tensile strength ( J:153292 )

• skin is extremely fragile and tears easily under mechanical stress

• tape stripping removes 3 times more protein compared to controls

growth/size/body

dermal cyst ( J:153292 )

• seen in dorsal skin grafted onto nude mice, characteristically result from degenerative hair follicles