All Phenotypes Shcbp1l<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shcbp1l^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4364718

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shcbp1l^{tm1a(KOMP)Wtsi}/Shcbp1l^{tm1a(KOMP)Wtsi}	involves: C57BL/6N	MGI:5750966

Allelic Composition	Shcbp1l^{tm1a(KOMP)Wtsi}/Shcbp1l^{tm1a(KOMP)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0042_4_G02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shcbp1l^{tm1a(KOMP)Wtsi} mutation (1 available); any Shcbp1l mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:228105 )

N	• sperm exhibit normal motility, capacitation and acrosome reaction • female mice exhibit normal fertility

oligozoospermia ( J:228105 )

• fewer than normal sperm content in whole epididymal

• however, the average number of motile and progressive sperm is normal

arrest of male meiosis ( J:228105 )

• arrest of metaphase and anaphase spermatocytes

abnormal meiotic spindle morphology ( J:228105 )

• spindle instability in male germs cells

increased male germ cell apoptosis ( J:228105 )

• at stages I-III and XII

decreased testis weight ( J:228105 )

decreased litter size ( J:228105 )

• when male mice are crossed with wild-type female mice

• however, female mice mated to wild-type males produce normal sized litters

reduced male fertility ( J:228105 )

• male mice crossed with wild-type female mice produce smaller litters than wild-type mice or female homozygotes crossed with wild-type mice

cellular

oligozoospermia ( J:228105 )

• fewer than normal sperm content in whole epididymal

• however, the average number of motile and progressive sperm is normal

arrest of male meiosis ( J:228105 )

• arrest of metaphase and anaphase spermatocytes

abnormal meiotic spindle morphology ( J:228105 )

• spindle instability in male germs cells

increased male germ cell apoptosis ( J:228105 )

• at stages I-III and XII

endocrine/exocrine glands

decreased testis weight ( J:228105 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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