Phenotypes associated with this allele

• Allele Symbol: Fam13a^{tm1e(KOMP)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364167
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fam13a^tm1e(KOMP)Wtsi/Fam13a^tm1e(KOMP)Wtsi	C57BL/6N-Fam13a^tm1e(KOMP)Wtsi	MGI:6363541

Genotype
MGI:6363541

hm1

• Allelic Composition: Fam13a^{tm1e(KOMP)Wtsi}/Fam13a^{tm1e(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Fam13a^{tm1e(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:258290 )

N • both sexes show normal body fat ratio and body fat distribution whether on a normal chow diet or a high-fat diet

decreased white fat cell size ( J:258290 )

• after 14 weeks on a high-fat diet, white adipocyte size is modestly decreased relative to that in wild-type controls

abnormal white adipose tissue physiology ( J:258290 )

• on a normal chow diet, IRS1 (insulin receptor substrate 1) protein expression is significantly reduced in white adipose tissue (WAT) but not in skeletal muscle or liver

• after 12 weeks on a high-fat diet, insulin-mediated Akt activation is significantly impaired in association with decreased IRS1expression in WAT, but not in skeletal muscle or liver

white adipose tissue inflammation ( J:258290 )

• after 14 weeks on a high-fat diet, mRNA expression of inflammatory genes is significantly increased in WAT relative to that in wild-type controls, suggesting WAT inflammation

• however, expression of inflammatory cytokines in WAT is normal on a normal chow diet

growth/size/body

growth/size/body region phenotype ( J:258290 )

N • both sexes show normal body weight gain whether on a normal chow diet or a high-fat diet

homeostasis/metabolism

increased circulating free fatty acids level ( J:258290 )

• after 14 weeks on a high-fat diet, serum levels of free fatty acids (FFAs) are higher than those in wild-type controls

impaired glucose tolerance ( J:258290 )

• on a normal chow diet, mice show a modest but significant impairment in glucose tolerance relative to wild-type controls

• after 12 weeks on a high-fat diet, mice show exacerbated glucose intolerance relative to wild-type controls

insulin resistance ( J:258290 )

• on a normal chow diet, mice show a modest but significant impairment in insulin sensitivity in the absence of WAT inflammation

• after 12 weeks on a high-fat diet, mice show exacerbated insulin resistance relative to wild-type controls

enhanced lipolysis ( J:258290 )

• after 14 weeks on a high-fat diet, serum levels of FFAs are increased, white adipocyte size is reduced, and expression of adipose triglyceride lipase (ATGL) in WAT is higher than that in wild-type controls, suggesting enhanced lipolysis in WAT

immune system

white adipose tissue inflammation ( J:258290 )

• after 14 weeks on a high-fat diet, mRNA expression of inflammatory genes is significantly increased in WAT relative to that in wild-type controls, suggesting WAT inflammation

• however, expression of inflammatory cytokines in WAT is normal on a normal chow diet