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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myo5atm1e(KOMP)Wtsi
targeted mutation 1e, Wellcome Trust Sanger Institute
MGI:4363512
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myo5atm1e(KOMP)Wtsi/Myo5atm1e(KOMP)Wtsi B6Brd;B6N-Tyrc-Brd Myo5atm1e(KOMP)Wtsi/Wtsi MGI:6273149
hm2
Myo5atm1e(KOMP)Wtsi/Myo5atm1e(KOMP)Wtsi involves: C57BL/6J * C57BL/6N MGI:5494692


Genotype
MGI:6273149
hm1
Allelic
Composition
Myo5atm1e(KOMP)Wtsi/Myo5atm1e(KOMP)Wtsi
Genetic
Background
B6Brd;B6N-Tyrc-Brd Myo5atm1e(KOMP)Wtsi/Wtsi
Cell Lines EPD0034_4_C03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5atm1e(KOMP)Wtsi mutation (0 available); any Myo5a mutation (265 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice exhibit a non-synchronous hair cycling phenotype with patches of the coat found at different stages of the follicle cycle, unlike in wild-type controls




Genotype
MGI:5494692
hm2
Allelic
Composition
Myo5atm1e(KOMP)Wtsi/Myo5atm1e(KOMP)Wtsi
Genetic
Background
involves: C57BL/6J * C57BL/6N
Cell Lines EPD0034_4_C03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5atm1e(KOMP)Wtsi mutation (0 available); any Myo5a mutation (265 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Diluted coat color in Myo5atm1e(KOMP)Wtsi/Myo5atm1e(KOMP)Wtsi mice

mortality/aging
• fewer than expected mice are obtained from mating heterozygous mice

pigmentation
• lighter grey coat color than wild-type mice
• lighter grey coat color than wild-type mice

hematopoietic system
N
• mice exhibit normal platelet count, mean platelet volume, red blood cell count, hematocrit, mean corpuscular volume and white blood cell count
• platelets exhibit normal granule biogenesis and secretion, integrin activation, calcium signaling and spreading

integument
• lighter grey coat color than wild-type mice





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory