Phenotypes associated with this allele

• Allele Symbol: Myo5a^{tm1e(KOMP)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363512
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo5a^tm1e(KOMP)Wtsi/Myo5a^tm1e(KOMP)Wtsi	B6Brd;B6N-Tyr^c-Brd Myo5a^tm1e(KOMP)Wtsi/Wtsi	MGI:6273149
hm2	Myo5a^tm1e(KOMP)Wtsi/Myo5a^tm1e(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5494692

Genotype
MGI:6273149

hm1

• Allelic Composition: Myo5a^{tm1e(KOMP)Wtsi}/Myo5a^{tm1e(KOMP)Wtsi}
• Genetic Background: B6Brd;B6N-Tyr^c-Brd Myo5a^{tm1e(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0034_4_C03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair cycle ( J:232539 )

♂ • mice exhibit a non-synchronous hair cycling phenotype with patches of the coat found at different stages of the follicle cycle, unlike in wild-type controls

Genotype
MGI:5494692

hm2

• Allelic Composition: Myo5a^{tm1e(KOMP)Wtsi}/Myo5a^{tm1e(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0034_4_C03

Diluted coat color in Myo5a^{tm1e(KOMP)Wtsi}/Myo5a^{tm1e(KOMP)Wtsi} mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:195694 )

• fewer than expected mice are obtained from mating heterozygous mice

pigmentation

diluted coat color ( J:195694 )

• lighter grey coat color than wild-type mice

hypopigmentation ( J:195694 )

• lighter grey coat color than wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:195694 )

N • mice exhibit normal platelet count, mean platelet volume, red blood cell count, hematocrit, mean corpuscular volume and white blood cell count

N • platelets exhibit normal granule biogenesis and secretion, integrin activation, calcium signaling and spreading

integument

diluted coat color ( J:195694 )

• lighter grey coat color than wild-type mice