All Phenotypes Mysm1<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mysm1^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4362924

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}	C57BL/6-Mysm1^{tm1a(KOMP)Wtsi}	MGI:5641692
hm2	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}	Not Specified	MGI:5449983
ht3	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺	Not Specified	MGI:5449985

Allelic Composition	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6-Mysm1^{tm1a(KOMP)Wtsi}
Cell Lines	EPD0019_1_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1^{tm1a(KOMP)Wtsi} mutation (2 available); any Mysm1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

belly spot ( J:209956 , J:232539 )

abnormal hair follicle morphology ( J:209956 )

• abnormalities in the hair follicles

distorted hair follicle pattern ( J:209956 , J:232539 )

• abnormal hair follicle patterning, with hair follicles no longer arranged as staggered rows of triplets (J:209956)

• defects in hair follicle organization and associated structures (J:232539)

abnormal hair cycle ( J:209956 )

• the hair follicle cycle is disturbed, with most hair follicles in telogen

abnormal epidermal layer morphology ( J:209956 )

• abnormalities in the interfollicular epidermis

• within the interfollicular epidermis, the scale pattern is completely disrupted, although regions of scale differentiation lacking the granular layer can still be seen

increased foot pad pigmentation ( J:232539 )

• foot pad hyperpigmentation

decreased tail pigmentation ( J:209956 , J:232539 )

• white tails (J:209956)

limbs/digits/tail

increased foot pad pigmentation ( J:232539 )

• foot pad hyperpigmentation

abnormal hindlimb morphology ( J:232539 )

abnormal tail morphology ( J:209956 )

decreased tail pigmentation ( J:209956 , J:232539 )

• white tails (J:209956)

short tail ( J:232539 )

curly tail ( J:232539 )

kinked tail ( J:209956 )

pigmentation

belly spot ( J:209956 , J:232539 )

increased foot pad pigmentation ( J:232539 )

• foot pad hyperpigmentation

decreased tail pigmentation ( J:209956 , J:232539 )

• white tails (J:209956)

Allelic Composition	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}
Genetic Background	Not Specified
Cell Lines	EPD0019_1_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1^{tm1a(KOMP)Wtsi} mutation (2 available); any Mysm1 mutation (41 available)

Data Sources

IMPC Data for Mysm1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:165965 )

IMPC - HMGU

abnormal coping response ( J:165965 )

IMPC - HMGU

tremors ( J:165965 )

IMPC - HMGU

trunk curl ( J:165965 )

IMPC - HMGU

abnormal gait ( J:165965 )

IMPC - HMGU

decreased locomotor activity ( J:165965 )

IMPC - HMGU

hyperactivity ( J:165965 )

IMPC - HMGU

growth/size/body

decreased lean body mass ( J:165965 )

IMPC - HMGU

decreased body weight ( J:165965 )

IMPC - HMGU

abnormal body length ( J:165965 )

IMPC - HMGU

decreased body length ( J:165965 )

IMPC - HMGU

hematopoietic system

decreased erythrocyte cell number ( J:165965 )

IMPC - HMGU

decreased hematocrit ( J:165965 )

IMPC - HMGU

decreased hemoglobin content ( J:165965 )

IMPC - HMGU

increased mean corpuscular hemoglobin concentration ( J:165965 )

IMPC - HMGU

increased mean corpuscular volume ( J:165965 )

IMPC - HMGU

increased granulocyte number ( J:165965 )

IMPC - HMGU

thrombocytosis ( J:165965 )

IMPC - HMGU

increased T cell number ( J:165965 )

IMPC - HMGU

decreased leukocyte cell number ( J:165965 )

IMPC - HMGU

decreased B cell number ( J:165965 )

IMPC - HMGU

decreased mature B cell number ( J:165965 )

IMPC - HMGU

increased IgG2b level ( J:165965 )

IMPC - HMGU

homeostasis/metabolism

decreased circulating cholesterol level ( J:165965 )

IMPC - HMGU

decreased circulating triglyceride level ( J:165965 )

IMPC - HMGU

increased circulating phosphate level ( J:165965 )

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:165965 )

IMPC - HMGU

immune system

increased granulocyte number ( J:165965 )

IMPC - HMGU

increased T cell number ( J:165965 )

IMPC - HMGU

decreased leukocyte cell number ( J:165965 )

IMPC - HMGU

decreased B cell number ( J:165965 )

IMPC - HMGU

decreased mature B cell number ( J:165965 )

IMPC - HMGU

increased IgG2b level ( J:165965 )

IMPC - HMGU

integument

abnormal coat/ hair morphology ( J:165965 )

IMPC - HMGU

abnormal coat/hair pigmentation ( J:165965 )

IMPC - HMGU

limbs/digits/tail

abnormal autopod morphology ( J:165965 )

IMPC - HMGU

abnormal hindlimb morphology ( J:165965 )

IMPC - HMGU

abnormal tail morphology ( J:165965 )

IMPC - HMGU

curly tail ( J:165965 )

IMPC - HMGU

kinked tail ( J:165965 )

IMPC - HMGU

pigmentation

abnormal coat/hair pigmentation ( J:165965 )

IMPC - HMGU

skeleton

abnormal vertebrae morphology ( J:165965 )

IMPC - HMGU

abnormal bone structure ( J:165965 )

IMPC - HMGU

abnormal bone mineralization ( J:165965 )

IMPC - HMGU

Allelic Composition	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺
Genetic Background	Not Specified
Cell Lines	EPD0019_1_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1^{tm1a(KOMP)Wtsi} mutation (2 available); any Mysm1 mutation (41 available)

Data Sources

IMPC Data for Mysm1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased mean corpuscular volume ( J:165965 )

IMPC - HAR

homeostasis/metabolism

decreased circulating triglyceride level ( J:165965 )

IMPC - HAR

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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