All Phenotypes Rdh10<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rdh10^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4362599

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N	MGI:5429764
ht2	Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^trex	involves: 129S1/Sv * C57BL/6J * C57BL/6N	MGI:5429765

Allelic Composition	Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^{tm1a(KOMP)Wtsi}
Genetic Background	involves: C57BL/6J * C57BL/6N
Cell Lines	EPD0149_1_D08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh10^{tm1a(KOMP)Wtsi} mutation (1 available); any Rdh10 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent pharyngeal arches ( J:185330 )

• absence of posterior arches

abnormal embryo turning ( J:185330 )

• defects in axial turning

abnormal rostral-caudal body axis extension ( J:185330 )

• body axis extension is impaired

embryonic growth retardation ( J:185330 )

• defects in embryo growth

• body axis extension is impaired

decreased embryo size ( J:185330 )

decreased somite size ( J:185330 )

• small somites

cardiovascular system

failure of heart looping ( J:185330 )

• unlooped and edemic hearts

abnormal heart tube morphology ( J:185330 )

• unlooped and edemic hearts

hearing/vestibular/ear

small otic vesicle ( J:185330 )

growth/size/body

embryonic growth retardation ( J:185330 )

• defects in embryo growth

• body axis extension is impaired

decreased embryo size ( J:185330 )

craniofacial

absent pharyngeal arches ( J:185330 )

• absence of posterior arches

Allelic Composition	Rdh10^{tm1a(KOMP)Wtsi}/Rdh10^trex
Genetic Background	involves: 129S1/Sv * C57BL/6J * C57BL/6N
Cell Lines	EPD0149_1_D08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh10^{tm1a(KOMP)Wtsi} mutation (1 available); any Rdh10 mutation (20 available)
Rdh10^trex mutation (0 available); any Rdh10 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:185330 )

abnormal embryonic tissue morphology ( J:185330 )

• display a range of phenotypes with the most severely affected mice resembling Rdh10^{tm1a(KOMP)Wtsi} homozygotes and the most mildly affected mice resembling Rdh10^trex

decreased somite size ( J:185330 )

• small somites

growth/size/body

decreased embryo size ( J:185330 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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