Rdh10^trex
Chemically induced Allele Detail

Summary

• Symbol: Rdh10^trex
• Name: retinol dehydrogenase 10 (all-trans); trex
• MGI ID: MGI:4437845
• Synonyms: trex
• Gene: Rdh10 Location: Chr1:16176106-16202774 bp, + strand Genetic Position: Chr1, 4.94 cM
• Alliance: Rdh10^trex page

Short forelimbs in E9.5-E10.5 Rdh10^trex/Rdh10^trex embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129S1/Sv or C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition at nucleotide 251 (NM_133832) that results in the amino acid substitution of arginine for cystinine. This mutation is predicted to disrupt the first beta strand of the protein. Residual Retinoic Acid signaling is detected in the trunk neural tube indicating this is a severely hypomorphic allele. (J:121229, J:185330)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	34 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	41 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rdh10 Mutation: 20 strains or lines available

References

• Original: J:121229 Sandell LL, et al., RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 2007 May 1;21(9):1113-24
• All: 8 reference(s)