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Allele Symbol Allele Name Allele ID |
Arhgap25tm1a(KOMP)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:4362243 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - WTSI
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IMPC - WTSI
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IMPC - WTSI
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IMPC - WTSI
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males, but not females, show decreased body weight over a 130-day period relative to wild-type controls
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• following intrascrotal recombinant murine (rm)TNF injection, mice show a significant increase in leukocyte extravasation into inflamed cremaster muscle tissue relative to wild-type controls; extravasated leukocytes are primarily neutrophilic granulocytes, followed by monocytes and lymphocytes, and eosinophils
• in a TNF-induced acute peritonitis model, mice show increased leukocyte extravasation into inflamed peritoneal tissue relative to wild-type controls
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• in TNF-stimulated (inflamed) cremaster muscle venules, mice show significantly reduced mean leukocyte rolling velocity relative to wild-type controls; however, no significant changes in leukocyte rolling flux fraction or leukocyte adhesion are observed
• in flow chambers coated with recombinant murine (rm)E-selectin, the number of rolling leukocytes is increased by 2.5-fold relative to that in wild-type controls
• in flow chambers coated with rmE-selectin or with rmE-selectin and rmICAM-1 surface, the mean leukocyte rolling velocity is significantly reduced relative to that in wild-type controls; however, no changes in leukocyte adhesion are observed when flow chambers are coated with rmE-selectin alone, with rmE-selectin and rmICAM-1, or with rmE-selectin, rmICAM-1, and rmCXCL-1.
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• in TNF-stimulated (inflamed) cremaster muscle venules, mice show significantly increased crawling velocity and Euclidean distance, indicating prolonged crawling relative to wild-type controls; however, no significant differences in crawling directionality or accumulated distance are observed
• in a Transwell migration assay, TNF-treated bone marrow neutrophils show a significant increase in transmigration toward CXCL12 relative to similarly treated wild-type neutrophils
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• in a TNF-induced acute peritonitis model, mice show a significantly increased number of Ly-6G+ neutrophils in peritoneal lavage relative to wild-type controls
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• TNF-treated bone marrow-derived neutrophils fail to show a decrease in GTP-bound Rac activity, unlike TNF-treated wild-type neutrophils
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• in a TNF-induced acute peritonitis model, mice show increased leukocyte infiltration into the peritoneal cavity relative to wild-type controls
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| N |
• mice exhibit normal blood parameters, including circulating cell counts, hematocrit, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, relative to wild-type controls
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• following intrascrotal recombinant murine (rm)TNF injection, mice show a significant increase in leukocyte extravasation into inflamed cremaster muscle tissue relative to wild-type controls; extravasated leukocytes are primarily neutrophilic granulocytes, followed by monocytes and lymphocytes, and eosinophils
• in a TNF-induced acute peritonitis model, mice show increased leukocyte extravasation into inflamed peritoneal tissue relative to wild-type controls
|
|
• in TNF-stimulated (inflamed) cremaster muscle venules, mice show significantly reduced mean leukocyte rolling velocity relative to wild-type controls; however, no significant changes in leukocyte rolling flux fraction or leukocyte adhesion are observed
• in flow chambers coated with recombinant murine (rm)E-selectin, the number of rolling leukocytes is increased by 2.5-fold relative to that in wild-type controls
• in flow chambers coated with rmE-selectin or with rmE-selectin and rmICAM-1 surface, the mean leukocyte rolling velocity is significantly reduced relative to that in wild-type controls; however, no changes in leukocyte adhesion are observed when flow chambers are coated with rmE-selectin alone, with rmE-selectin and rmICAM-1, or with rmE-selectin, rmICAM-1, and rmCXCL-1.
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• in TNF-stimulated (inflamed) cremaster muscle venules, mice show significantly increased crawling velocity and Euclidean distance, indicating prolonged crawling relative to wild-type controls; however, no significant differences in crawling directionality or accumulated distance are observed
• in a Transwell migration assay, TNF-treated bone marrow neutrophils show a significant increase in transmigration toward CXCL12 relative to similarly treated wild-type neutrophils
|
|
• in a TNF-induced acute peritonitis model, mice show a significantly increased number of Ly-6G+ neutrophils in peritoneal lavage relative to wild-type controls
|
|
• TNF-treated bone marrow-derived neutrophils fail to show a decrease in GTP-bound Rac activity, unlike TNF-treated wild-type neutrophils
|
|
• following intrascrotal recombinant murine (rm)TNF injection, mice show a significant increase in leukocyte extravasation into inflamed cremaster muscle tissue relative to wild-type controls; extravasated leukocytes are primarily neutrophilic granulocytes, followed by monocytes and lymphocytes, and eosinophils
• in a TNF-induced acute peritonitis model, mice show increased leukocyte extravasation into inflamed peritoneal tissue relative to wild-type controls
|
|
• in TNF-stimulated (inflamed) cremaster muscle venules, mice show significantly reduced mean leukocyte rolling velocity relative to wild-type controls; however, no significant changes in leukocyte rolling flux fraction or leukocyte adhesion are observed
• in flow chambers coated with recombinant murine (rm)E-selectin, the number of rolling leukocytes is increased by 2.5-fold relative to that in wild-type controls
• in flow chambers coated with rmE-selectin or with rmE-selectin and rmICAM-1 surface, the mean leukocyte rolling velocity is significantly reduced relative to that in wild-type controls; however, no changes in leukocyte adhesion are observed when flow chambers are coated with rmE-selectin alone, with rmE-selectin and rmICAM-1, or with rmE-selectin, rmICAM-1, and rmCXCL-1.
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• in TNF-stimulated (inflamed) cremaster muscle venules, mice show significantly increased crawling velocity and Euclidean distance, indicating prolonged crawling relative to wild-type controls; however, no significant differences in crawling directionality or accumulated distance are observed
• in a Transwell migration assay, TNF-treated bone marrow neutrophils show a significant increase in transmigration toward CXCL12 relative to similarly treated wild-type neutrophils
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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