Phenotypes associated with this allele

• Allele Symbol: Wnk1^tm1Clhu
• Allele Name: targeted mutation 1, Chou-Long Huang
• Allele ID: MGI:4360972
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wnk1^tm1Clhu/Wnk1^tm1Clhu Tg(Tek-cre)12Flv/0	involves: C3H * C57BL/6	MGI:4360979

Genotype
MGI:4360979

cn1

• Allelic Composition: Wnk1^tm1Clhu/Wnk1^tm1Clhu; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:152906 )

• all die before E13.5

cardiovascular system

abnormal dorsal aorta morphology ( J:152906 )

• at E10.5, dorsal aortae are collapsed

abnormal brain vasculature morphology ( J:152906 )

• at E10.5 the density of vessels in the head is reduced

abnormal vascular branching morphogenesis ( J:152906 )

• reduced branching angiogenesis

abnormal cardinal vein morphology ( J:152906 )

• at E10.5 the cardinal veins are collapsed

abnormal vitelline vasculature morphology ( J:152906 )

• at E10.5, lack visible large vessels

abnormal myocardial trabeculae morphology ( J:152906 )

• reduced at E10.5

thin myocardium ( J:152906 )

• at E10.5

heart hypoplasia ( J:152906 )

• at E10.5 all 4 chambers are formed but are hypoplastic

pericardial edema ( J:152906 )

• at E10.5

embryo

abnormal vitelline vasculature morphology ( J:152906 )

• at E10.5, lack visible large vessels

decreased embryo size ( J:152906 )

• at E10.5

abnormal vitelline vascular remodeling ( J:152906 )

• at E10.5 the primitive plexus has failed to remodel

homeostasis/metabolism

pericardial edema ( J:152906 )

• at E10.5

growth/size/body

decreased embryo size ( J:152906 )

• at E10.5

muscle

abnormal myocardial trabeculae morphology ( J:152906 )

• reduced at E10.5

thin myocardium ( J:152906 )

• at E10.5

nervous system

abnormal brain vasculature morphology ( J:152906 )

• at E10.5 the density of vessels in the head is reduced