Phenotypes associated with this allele

• Allele Symbol: Wnk4^tm2.1Suc
• Allele Name: targeted mutation 2.1, Shinichi Uchida
• Allele ID: MGI:4360633
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnk4^tm2.1Suc/Wnk4^tm2.1Suc	involves: 129S4/SvJae * C57BL/6	MGI:4360644

Genotype
MGI:4360644

hm1

• Allelic Composition: Wnk4^tm2.1Suc/Wnk4^tm2.1Suc
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine potassium level ( J:152915 )

• when fed a low-potassium diet

increased urine sodium level ( J:152915 )

• at days 5, 6, and 7 under a low-salt diet and during the transitional period from low- to high-salt diet, mice exhibit increased sodium excretion compared with similarly treated wild-type mice

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:152915 )

• when fed a normal or low-salt diet, mice exhibit decreased systolic blood pressure during active periods compared with similarly treated wild-type mice

homeostasis/metabolism

increased urine potassium level ( J:152915 )

• when fed a low-potassium diet

increased urine sodium level ( J:152915 )

• at days 5, 6, and 7 under a low-salt diet and during the transitional period from low- to high-salt diet, mice exhibit increased sodium excretion compared with similarly treated wild-type mice