Wnk4^tm2.1Suc
Targeted Allele Detail

Summary

• Symbol: Wnk4^tm2.1Suc
• Name: WNK lysine deficient protein kinase 4; targeted mutation 2.1, Shinichi Uchida
• MGI ID: MGI:4360633
• Synonyms: WNK4deltaEx7-8
• Gene: Wnk4 Location: Chr11:101151393-101168235 bp, + strand Genetic Position: Chr11, 64.51 cM
• Alliance: Wnk4^tm2.1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152915
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exon 7 and the neo cassette. Western blot analysis confirmed the production of two protein products from alternative spliced transcripts that fuses exon 6 to exon 8 (63 KDa) or exon 6 to exon 9 (49 KDa). Authors state that this is a hypomorphic allele. (J:152915)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk4 Mutation: 58 strains or lines available

References

• Original: J:152915 Ohta A, et al., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86
• All: 1 reference(s)