Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prom1tm1.1(DTA)Toko mutation
(0 available);
any
Prom1 mutation
(75 available)
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vision/eye
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• at P30
• however, mice raised in complete darkness exhibit photoreceptor retention
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• Background Sensitivity: at P20, mice on a congenic C57BL/6 background exhibit loss of the photoreceptor cell layer including the outer segment with missing cell body that is more severe than in mice on a mixed background
• however, retinal structure at P14 is normal
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• Background Sensitivity: unlike in mice on a mixed background
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• Background Sensitivity: at P20 unlike in mice on a mixed background
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• Background Sensitivity: more severe than in mice on mixed background
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• Background Sensitivity: more severe than in mice on mixed background
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nervous system
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• at P30
• however, mice raised in complete darkness exhibit photoreceptor retention
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• Background Sensitivity: at P20, mice on a congenic C57BL/6 background exhibit loss of the photoreceptor cell layer including the outer segment with missing cell body that is more severe than in mice on a mixed background
• however, retinal structure at P14 is normal
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prom1tm1.1(DTA)Toko mutation
(0 available);
any
Prom1 mutation
(75 available)
|
|
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vision/eye
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• at P30
• however, mice raised in complete darkness or treated with fenretinide exhibit photoreceptor retention
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• layer is absent by 4 months
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• disorganized and misaligned at P20
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• layer is absent by 4 months
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• Background Sensitivity: mice on a mixed background exhibit less extensive loss of the outer plexiform layer, the outer nuclear layer and outer segment to inner segment compared with mice on a congenic C57BL/6 background
• however, the inner nuclear layer and inner plexiform layer are largely unaffected
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• Background Sensitivity: not as severe as in mice on a congenic C57BL/6 background at P20
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• layer is absent by 4 months
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• Background Sensitivity: not as severe as in mice on a congenic C57BL/6 background at P20
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• reduced a- and b-wave amplitudes
• however, mice raised in complete darkness exhibit rescued function
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• reduced a- and b-wave amplitudes
• however, mice raised in complete darkness or treated with fenretinide exhibit rescued function
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nervous system
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• at P30
• however, mice raised in complete darkness or treated with fenretinide exhibit photoreceptor retention
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• layer is absent by 4 months
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• disorganized and misaligned at P20
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• layer is absent by 4 months
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• Background Sensitivity: mice on a mixed background exhibit less extensive loss of the outer plexiform layer, the outer nuclear layer and outer segment to inner segment compared with mice on a congenic C57BL/6 background
• however, the inner nuclear layer and inner plexiform layer are largely unaffected
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prom1tm1.1(DTA)Toko mutation
(0 available);
any
Prom1 mutation
(75 available)
|
|
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normal phenotype
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• mice are viable and develop normally
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prom1tm1.1(DTA)Toko mutation
(0 available);
any
Prom1 mutation
(75 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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nervous system
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• tamoxifen treated mice exhibit increased apoptosis in the granular layer of the cerebellum, cortex of telencephalon, white matter and midbrain unlike similarly treated and untreated control mice
• however, ventricular zone cells and their neurogenesis are normal in tamoxifen treated mice
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growth/size/body
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• tamoxifen treated mice exhibit reduced body weight compared with untreated and treated control mice
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behavior/neurological
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• tamoxifen treated mice exhibit walking abnormalities
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cellular
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• tamoxifen treated mice exhibit increased apoptosis in the granular layer of the cerebellum, cortex of telencephalon, white matter and midbrain unlike similarly treated and untreated control mice
• however, ventricular zone cells and their neurogenesis are normal in tamoxifen treated mice
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Analysis Tools